Syntheses of 2-(2-quinoxalyl)-1-phenylethanone and related ethanones

Abstract

Nine 2-(2-quinoxalyl)-1-phenylethanones were synthesized by the condensation of 2-methylquinoxaline and the requisite methyl benzoate ester with sodium hydride as the condensing agent. Substituents in the 3 or 4 positions of the phenyl ring were methyl, methoxy, chloro, or trifluoromethyl.