Syntheses of [18F]5-fluoro-3-nitro-l-tyrosine

Biocatalytic One-Pot Synthesis of l-Tyrosine Derivatives from Monosubstituted Benzenes, Pyruvate, and Ammonia

“…In addition, it constitutes an important biochemical marker for human l -amino-acid decarboxylase deficiency. , Chemical de novo synthesis of tyrosine derivatives proceeds through several steps and leads to racemic material, which requires late-stage racemate resolution. Direct functionalization of l -Tyr is based on protective group chemistry or needs harsh reagents, such as F 2 or HNO 3 . In order to shortcut chemical synthesis, a biocatalytic C–C coupling was developed employing tyrosine phenol lyase mutant M379V (TPL) from Citrobacter freundii .…”

Methods for 11C‐ and 18F‐labelling of amino acids and derivatives for positron emission tomography imaging

“…However, in all cases, the process leads to regio‐isomers of the desired amino acid that have to be separated. Using this approach, 6‐[ 18 F]fluoro‐ l ‐dopa, 2‐[ 18 F]fluoro‐ l ‐tyrosine, 3‐[ 18 F‐]fluoro‐ l ‐tyrosine, 3‐[ 18 F]fluoro‐α‐methyl‐ l ‐tyrosine, 3,5‐di‐[ 18 F]fluoro‐ l ‐tyrosine, 3,5‐di[ 18 F]fluoro‐α‐methyl‐ l ‐tyrosine, 2‐ and 6‐[ 18 F‐]fluoro‐meta‐tyrosine, 2‐, 3‐ and 4‐[ 18 F]fluorophenyphenyl‐alanine, 5‐[ 18 F]fluoro‐3‐nitro‐ l ‐tyrosine, 4‐dihydroxyboryl‐2‐[ 18 F]fluorophenylalanine, 6‐[ 18 F]fluoro‐ O ‐pivaloyl‐ l ‐dopa, 3‐[ 18 F]fluoro‐α‐fluoromethyl‐ l ‐tyrosine, 2‐ and 4‐[ 18 F]fluoro‐β‐fluoromethylene‐m‐tyrosine and 5‐hydroxy‐ l ‐tryptophan were synthesized.…”