Abstract:Triazole derivatives
Triazole derivatives R 0280Syntheses of 1-(4-Methylsulfonylphenyl)-5-aryl-1,2,3-triazoles and 1-(4-Aminosulfonylphenyl)-5-aryl-1,2,3-triazoles. -Biaryltriazoles (VI) and (XII) are synthesized as possible COX-2 inhibitors. Some reaction steps according to literature methods are slightly modified to start the reaction or to improve the reaction yields. For example, potassium permanganate oxidation of (V) in an acetone solution affords the desired product (VI) only in low yield. However, this… Show more
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