Syntheses, characterization, antimicrobial and genotoxic activities of new Schiff bases and their complexes

Abstract

Two new Schiff base ligands (L 1 , L 2 ) have been prepared from the reaction of 2,6-diacetylpyridine and 2-pyridinecarboxyaldehyde with 4-amino-2,3-dimethyl-1-phenyl-3-pyrozolin-5-on, and their Co(II), Cu(II), Ni(II), Mn(II), and Cr(III) metal complexes have also been prepared. The complexes are formed by coordination of N and O atoms of the ligands. Their structures were characterized by physico-chemical and spectroscopic methods. The analytical data shows that the metal to ligand ratio in the Schiff base complexes is 1:2. The Schiff base ligands and all complexes were evaluated for their in vitro antibacterial and antifungal activities by the disc diffusion method. In addition, the genotoxic properties of the ligands were studied.

Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review

“…Ispir et al [63] described the Schiff bases of 2,6diacetylpyridine and 2-pyridine carboxaldehyde with 4-amino-2,3-dimethyl-1-phenyl-3-pyrozolin-5-one[4,4'-(1E,1 0 E)-(1,1'-(pyridine-2,6-diyl)bis(ethan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene) bis(1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H) one) (27), and (E)-1,5-dimethyl-2-phenyl-4-(1-(pyridin-2-yl)ethylideneamino)-1Hpyrazol-3(2H)-one (28)] and their Co (II), Cu (II), Ni (II), Mn (II) and Cr (III) complexes (29e38) (Scheme 9) exhibit antibacterial and antifungal activities against E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Mycobacterium smegmatis, P. aeruginosa, Enterobacter cloacae, and Micrococcus leteus.…”

Antileishmanial, Antimicrobial and Antifungal Activities of Some New Aryl Azomethines

“…Moreover, the drugs currently in use are expensive, require long-term treatment [ 4 ], display high liver and heart toxicities, develop clinical resistance after few weeks of treatment and currently contribute to increase leishmaniasis-AIDS co-infections in some countries [ 5 , 6 ]. Azomethines are characterized by the –CH=N- (imino group) which has special importance in elucidating the mechanism of transmination and racemization in biological system [ 7 , 8 , 9 ]. Azomethines have high potential chemical permutation possibilities and show diuretic [ 10 ], anticancer [ 11 , 12 , 13 , 14 ], antibacterial [ 15 , 16 , 17 , 18 , 19 ], and antifungal activities [ 20 , 21 , 22 ].…”

The zwitterion of N-(2-carboxyphenyl)-4-dimethylaminebenzylideneimine

“…These compounds are often used as ligands in coordination chemistry and some of their first-row transition metal complexes exhibit enhanced biological properties [5][6][7]. They also have applications in organic synthesis, catalysis, biotechnology, and analytical chemistry [8][9][10][11].…”