Syntheses, characterization and molecular structures of calcium(II) and copper(II) complexes bearing O2-chelate ligands: DNA binding, DNA cleavage and anti-microbial study

Jadeja, R.N.; Vyas, Komal M.; Gupta, Vivek K.; Joshi, Rushikesh G.; Prabha, C. Ratna

doi:10.1016/j.poly.2011.11.004

Cited by 34 publications

(18 citation statements)

References 42 publications

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“…Jadeja and co-workers [41] synthesized multiple pyrazolonebased complexes and evaluated the bioactivity. The consequence indicated that compound 55 ( Fig.…”

Section: Coordination Pyrazolone Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

136

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a b s t r a c tThe pyrazolone structural motif is a critical element of drugs aimed at different biological end-points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates with several medicinal features including antimicrobial, antitumor, CNS (central nervous system) effect, anti-inflammatory activities and so on. Meanwhile, SAR (Structure-Activity Relationship) investigations have drawn attentions among medicinal chemists, along with a plenty of analogues have been derived for multiple targets. In this review, we comprehensively summarize the biological activity and SAR for pyrazolone analogues, wishing to give an overall retrospect and prospect on the pyrazolone derivatives.

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“…Jadeja and co-workers [41] synthesized multiple pyrazolonebased complexes and evaluated the bioactivity. The consequence indicated that compound 55 ( Fig.…”

Section: Coordination Pyrazolone Compounds As Antimicrobial Agentsmentioning

confidence: 99%

Pyrazolone structural motif in medicinal chemistry: Retrospect and prospect

Zhao

Dai

et al. 2020

European Journal of Medicinal Chemistry

136

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Section: Introductionmentioning

confidence: 99%

“…Acyl pyrazolones are widely used in coordination chemistry due to the nature of the bidentate ligand . A wide range of applications has been studied in the field of biological activity of metal complexes of acyl pyrazolone . The d 10 metal complexes of the acyl pyrazolones and their structural analogues showed decent fluorescence properties, antimicrobial and antitumor activity .…”

Section: Introductionmentioning

confidence: 99%

Binary and Ternary Zinc(II) Complexes of Acyl Pyrazolones: Synthesis, Spectroscopic Analysis, Crystal Structure and Antimalarial Activity

et al. 2019

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A new series of Zn II metal complexes of ligands 4-(4chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3one (PCBPMP) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4dihydro-3H-pyrazol-3-one (PCBTPMP) were prepared and characterized. The nature of bonding and the stereochemistry of the complexes were deduced from 1 H and 13 C Nuclear Magnetic Resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Molar conductivity measurements and Single-crystal X-ray diffraction. The analyses indicated that complexes 1, 2 and 3 are mononuclear and exhibited octahedral geometry around Zn II . The potential in silico and in vitro antimalarial activity inhibits Plasmodium falciparum and the same was exhibited by Ligands and Zinc complexes. This would be the first report of the antimalarial activity of Zinc complexes of acyl pyrazolones ligand.[a] I.

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“…This band is shifted to lower wave number and its intensity drastically affected in the copper complexes due to coordination with metal ion [6][7][8]. The critical observation is that the strong band at around 1670 cm À1 in the ligands which is assignable to t C@O (cyclic), disappears completely in the complexes further supports the complex formation with ketonic oxygen of the pyrazolone [6][7][8]. The complexes show additional bands within the range 585-595 cm À1 and 470-490 cm À1 due to the t MAN and t MAO , which confirms the coordination of the ligand with copper metal [20].…”

Section: Ir Spectramentioning

confidence: 99%

“…Numerous Schiff base ligands of pyrazolones and their metal complexes have been reported in the literatures. Schiff bases of pyrazolones and their metal complexes are reported to be superior reagents in biological, clinical and analytical applications [6][7][8][9][10]. Pyrazolones are used in analytical chemistry for the determination and isolation of almost all metal ions due to their high extracting ability, intense color of the complex extracts and low solubility of the complex in some solvents [11].…”

Section: Introductionmentioning

confidence: 99%