Syntheses, characterization and antimicrobial activity of silver(I) complexes containing 2-hydroxymethyl-N-alkylimidazole ligands

Kleyi, Phumelele; Walmsley, Ryan S.; Fernandes, Manuel A.; Torto, Nelson; Tshentu, Zenixole R.

doi:10.1016/j.poly.2012.04.017

Cited by 20 publications

(32 citation statements)

References 31 publications

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“…These results are somewhat at variance with those observed for the Ag(I) complexes containing 2-hydroxymethyl-N-alkylimidazole ligands where, dependant on the chain length of the alkyl substituent on the imidazole, the activity against E. coli, S. aureus and B. spirizizenii exceeded that for C. albicans [5]. In terms of Ag(I) content, there was no significant difference in the antibacterial and antifungal activities of 1-4 and 6 compared to those of the Ag(I) complexes containing N1-substituted imidazole and 9-aca À ligands [6].…”

Section: Biological Activitycontrasting

confidence: 62%

“…For example, Kleyi et al [5] studied the antimicrobial activity of a family of 2-hydroxymethyl-N-alkylimidazole ligands and their Ag(I) complexes and found that whereas the metal-free ligands were poorly active against Escherichia coli and Candida albicans, imidazoles with long pendant alkyl chains displayed high activity against Staphylococcus aureus and Bacillus spizizenii. Ag(I) complexes containing imidazole ligands with shorter alkyl chains were more active against E. coli, whilst those with longer chains displayed higher activity against B. spizizenii.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

et al. 2013

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a b s t r a c t[Ag 2 (9-aca) 2 ] (9-acaH = 9-anthracenecarboxylic acid) interacts with DMSO and a selection of substituted imidazoles giving [Ag 4 (DMSO) 4 (9-aca) 4 In the carboxylate/imidazole complexes 2-4, the imidazole ligand is in the neutral form, whilst in complexes 6-9 the imidazolate ligand is deprotonated and no carboxylate ligand is present. Attempted recrystallization of 4 from EtOH gives the metal-free, imidazolium salt, 2-Mebenz-imH 2 )(9-aca)ÁH 2 O (5). The X-ray crystal structures of complexes 1 and 2 and the salt 5 were determined. Antimicrobial screening showed that the Ag(I) complexes were substantially more active against the fungus Candida albicans than the bacterial species, methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Some of the complexes offer a good prognosis for Galleria mellonella (larvae of the greater wax moth) infected with a lethal dose of C. albicans cells.

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Section: Biological Activitycontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

et al. 2013

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“…The 1-R-imidazole-2-carboxylic acids were prepared from the corresponding imidazole-2-carboxaldehydes by the hydrogen peroxide facilitated oxidation in water [37,38]. This reaction requires no heating and water was the only by-product of oxidation, making it an environmentally friendly option.…”

Section: Synthesis and General Considerationsmentioning

confidence: 99%

pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes

Gundhla

Walmsley

Ugirinema

et al. 2015

Journal of Inorganic Biochemistry

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“…Silver has the most outstanding properties among all metals with antimicrobial activity because of its higher toxicity to microorganisms and lower toxicity to mammalian cells . The antimicrobial activities of both colloidal silver and silver ions have been known since ancient times.…”

Section: Introductionmentioning

confidence: 99%

Heteroleptic complexes of antifungal drugs with the silver ion

Giulidori

Mosconi

Toplikar

et al. 2016

J of Physical Organic Chem

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In spite of a large number of antibiotics and chemotherapeutics available for medical use, the emergence of old and new antibiotic resistance in the last decades revealed a substantial medical need for new classes of antimicrobial agents. In this paper we report the synthesis, characterization by elemental analysis, Fourier transform infrared and Nuclear magnetic resonance spectroscopies, and antifungal properties of two heteroleptic complexes of albendazole (albz) with Ag(I), using KSCN and o‐phenanthroline (phen) as the second ligand, respectively. Both complexes showed a moderate antifungal activity with all the assayed fungi, mainly Candida albicans and Candida tropicalis, that showed no activity against albendazole. Copyright © 2016 John Wiley & Sons, Ltd.

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Syntheses, characterization and antimicrobial activity of silver(I) complexes containing 2-hydroxymethyl-N-alkylimidazole ligands

Cited by 20 publications

References 31 publications

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

pH-metric chemical speciation modeling and studies of in vitro antidiabetic effects of bis[(imidazolyl)carboxylato]oxidovanadium(IV) complexes

Heteroleptic complexes of antifungal drugs with the silver ion

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