Syntheses and structures of and catalysis of hydrolysis by Zn(II) complexes of chelating pyridyl donor ligands

Gultneh, Yilma; Khan, Amir; Blaise, Die; Chaudhry, Sohail; Ahvazi, Bijan; Marvey, Bassie B.; Butcher, Ray J.

doi:10.1016/s0162-0134(99)00025-2

Cited by 98 publications

(69 citation statements)

References 52 publications

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“…107,108 It is suggested that the high occurrence of Zn(II) in biological systems is due to the abundance of soluble forms of this element in the environment. 108 The advantages of having Zn(II) in an active site of an enzyme include its high Lewis acidity, which is mostly influenced by the ionic potential Z eff /r (Z eff = effective electrical charge, r = effective radius of the ion), 108 and the coordination flexibility of Zn(II) arising from its d 10 configuration.…”

Section: Dinuclear Zinc Hydrolase Mimicsmentioning

confidence: 99%

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

et al. 2014

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An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

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Section: Dinuclear Zinc Hydrolase Mimicsmentioning

confidence: 99%

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

et al. 2014

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“…Accordingly, Dpa ligands have been used as such, [11] but more widely as linked ligand units in larger host structures. [12,13] Recently, examples of Dpa-functionalized metal-anion fluorescence probes have been reported in which Dpa units have been linked to a fluorescent host molecule. [13b, [14][15][16] Lately, it has also been demonstrated that bimetallic double Dpa chelates can function in molecular recognition of anionic species, for example, phosphate, [17] pyrophosphate, [18] or phospholipid [19] anions, as well as histidine residues to some extent.…”

Section: Introductionmentioning

confidence: 99%

Development of Bis(2‐picolyl)amine–Zinc Chelates for Imidazole Receptors

Routasalo¹,

Helaja²,

Kavakka

et al. 2008

Eur J Org Chem

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New phenyl and phenol bis(2‐picolyl)amine (Dpa) derivatives have been synthesized in order to generate zinc chelates for imidazole anion receptors. Previously, binuclear phenolic zinc and copper chelates have shown affinity for pyrophosphate and guanidine anions, respectively. Herein we report significant imidazole affinity increasing from 2.38 × 106 to 2.90 × 107 for phenol‐bridged binuclear zinc–Dpa chelates, as evidenced by dynamic and titration 1H NMR studies. Among the Dpa chelates investigated, the zinc‐coordinated phenol group plays a crucial role in the mechanism of anion binding. Low‐temperature 1H NMR experiments suggest a σν‐symmetric geometry for the imidazole chelate. Computational DFT studies at the B3LYP level of theory imply that imidazole binding displaces the phenol bridge between the zinc ions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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“…The LOQ is always higher than the LOD and is often taken as fixed multiple of the LOD (usually double times higher than LOD value). The LOQ is determined by the same way as LOD: LOQ = yB + 10SD ( 7 ) or calculated directly from the LOD [18]:…”

Section: Sensitivity Of the Methodsmentioning

confidence: 99%

“…Sensitivity of the proposed methods is also determined by calculating Sandell's sensitivity (µg/cm 2 /0.001 Abs unit), which can be defined as the smallest weight of substance that can be detected in column of unit cross section [18]. The values of LOD, LOQ and Sandell's sensitivity are given in Table 3.…”

Section: Sensitivity Of the Methodsmentioning

confidence: 99%

“…A wide variety of spectrophotometric reagent, such as 2-arylthio-p-nitroacetophenone [9] and 2-(2-quino lylazo)-5-diethylaminobenzoic acid [10], 2-(5-bromo-2-pyridyl azo)-5-diethylaminophenol [11], 2-(2-benzothiazolylazo)-5-dimethylamino-4-tolylarsonic acid [12], 1-(2-quino lylazo)-2,4,5-trihydroxybenzen (QATB) [13], 2-hydroxy-5-methylaceto phenoneisonicotinoylhydrazone (HMAINH) [14] and benzilthio semicarbazide [15] are used as reagent for spectrophotometric determination of Pd(II) ion. On the other hand, pyridylamines find a large application in the field of coordination and analytical chemistry with different metal ions due to their potential biological, spin transition, organometallic and catalytic activities [16][17][18][19]. Among others, 2-hydrazinopyridine (hzpy) is an extremely potential ligand for complex formation with metal ions.…”

Section: Introductionmentioning

confidence: 99%

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Spectrophotometric determination of palladium using 2-hydraziniopyridine

2014

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KEYWORDSRapid, simple, sensitive and validated spectrophotometric method has been described for the determination of palladium (II) using 2-hydrazinopyridine. The complex product was quantitatively measured at 510 nm and the reaction conditions were studied and optimized. The stoichiometry and the stability constant of the purple colored complex has been determined spectrophotometrically in aqueous solution at 25 o C using Job's continuous variation and the molar ratio methods. The complex has 1:1 (M:L) molar ratio and Beer's plot was linear in the concentration ranges 1.06-9.00 μg/mL with corresponding molar absorptivity 2.978×10 3 L/mol.cm. The limits of detection and Sandell's sensitivity were also evaluated. The accuracy was evaluated as the % recovery (96.61-102.58) and precision was evaluated as RSD% (0.04-0.41) using inter-day and intraday analyses of multiple samples. The effect of various diverse ions on the determination of Pd(II) has been investigated.

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Syntheses and structures of and catalysis of hydrolysis by Zn(II) complexes of chelating pyridyl donor ligands

Cited by 98 publications

References 52 publications

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Development of Bis(2‐picolyl)amine–Zinc Chelates for Imidazole Receptors

Spectrophotometric determination of palladium using 2-hydraziniopyridine

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