Syntheses and spectroscopic studies on zinc(II) and mercury(II) complexes of isatin-3-thiosemicarbazone

Akinchan, Narayan T.; Drożdżewski, Piotr; Hölzer, W.

doi:10.1016/s0022-2860(02)00134-5

Cited by 27 publications

(33 citation statements)

References 10 publications

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“…The synthesis and properties of IS-TSC [27], IS-MTSC [12], and IS-DMTSC [12] were reported. A few more recent studies describe the synthesis and structural characterization of transition metal complexes of thiosemicarbazones derived from isatin and its derivatives [30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

Silva

Albu

2007

Open Chemistry

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Hybrid density functional theory calculations at the mPW1PW91/6-31+G(d,p) level of theory have been used to investigate the optimized structures and other molecular properties of five different series of thiosemicarbazones. The investigated compounds were obtained from acenaphthenequinone, isatin and its derivatives, and alloxan. The focus of the study is the isomerism and the NMR characterization of these thiosemicarbazones. It was found that only one isomer is expected for thiosemicarbazones and methylthiosemicarbazones, while for dimethylthiosemicarbazones, two isomers are possible. All investigated thiosemicarbazones exhibit a hydrazinic proton that is highly deshielded and resonates far downfield in the proton NMR spectra. This proton is a part of a characteristic sixmembered ring, and its NMR properties are a result of its strong, intermolecular hydrogen bond. The relationships between the calculated 1 H and 13 C NMR chemical shifts and various geometric parameters are reported.

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Section: Introductionmentioning

confidence: 99%

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

Silva

Albu

2007

Open Chemistry

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“…The C=N transitions due to n- for isatin-3-thiosemicarbazones were assigned as 2070 cm -1 (483 nm) of (Akinchan et al, 2002). This band was found to be 372, 373, 370, 370 nm for compounds 5, 18, 19, and 20, respectively.…”

Section: Electronic Spectrummentioning

confidence: 94%

“…At the level of TDBP86-CEP-31G*, this band for compounds 5, 18, 19, and 20 was found at 382 nm, which arises from 3-1', 2-1', 3-1', and 3-1' transitions. The bands due to -* transitions of semicarbazone group for isatin-3-thiosemicarbazone were between the range of 400-286 nm (Akinchan et al, 2002). Band at…”

Section: Electronic Spectrummentioning

confidence: 96%

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Quantum Chemical Calculations for some Isatin Thiosemicarbazones

Kandemi̇rlı¹,

Choudhary²,

Siddiq³

et al. 2012

Quantum Chemistry - Molecules for Innovations

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“…46 Zinc(II) and mercury(II) complexes of isatin-3-thiosemicarbazone were isolated and spectroscopically characterized. 47 Copper(II), nickel(II) and cobalt(II) complexes with pyridyl-and quinolylhydrazones of isatin and N-methylisatin have also been prepared. In the case of the copper complex, spectroscopic results suggested a planar geometry.…”

Section: Oxindoles As Ligands For Copper and Other Metal Ionsmentioning

confidence: 99%

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Cerchiaro

Ferreira

2006

J. Braz. Chem. Soc.

159

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Oxindóis são compostos endógenos encontrados em fluidos e tecidos de mamíferos. Particularmente, isatina (1H-indol-2,3-diona) e seus derivados vêm mostrando uma grande variedade de efeitos no meio biológico, incluindo a inibição de monoamina oxidase, atividade bactericida, fungicida, antiviral e antiproliferativa. Pesquisas mais recentes descrevem estes compostos como inibidores de quinases, uma classe de proteínas envolvidas em várias etapas do ciclo celular. Nesta revisão, complexos de cobre(II) com ligantes derivados de oxindóis são discutidos como potenciais agentes antitumorais, em comparação com outros complexos, com base na proposição de se aliar as propriedades redox e coordenativas do metal à capacidade de afetar os processos de angiogenese e apoptose já demonstrada por esse tipo de ligante.Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.

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Syntheses and spectroscopic studies on zinc(II) and mercury(II) complexes of isatin-3-thiosemicarbazone

Cited by 27 publications

References 10 publications

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

Quantum Chemical Calculations for some Isatin Thiosemicarbazones

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

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