Syntheses and self-assembly of novel polyurethane–itaconic acid copolymer hydrogels

Jiang, Guichang; Tuo, Xinlin; Wang, Dongrui; Liu, Junpeng

doi:10.1016/j.reactfunctpolym.2009.11.010

Cited by 16 publications

(5 citation statements)

References 29 publications

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“…They possess the hydrodynamic characteristics of cells in terms of their elastic, soft and tissue like physical properties. 147 In addition, the high chain mobility and surface hydrophilicity of hydrogels contribute to reduced protein adsorption and inhibited cell adhesion, and thus improve the biocompatibility. 148 As a result, they are the first biomaterial developed for application in the human body.…”

Section: Self-assembled Polyurethane Nanogels As Injectable Drug Deli...mentioning

confidence: 99%

Self-assembly of biodegradable polyurethanes for controlled delivery applications

et al. 2012

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The self-assembly of biodegradable polyurethanes constitutes an important area of research for the development of polymeric materials in biomedicine. In particular, colloidal polyurethane assemblies can increase the solubility and stability of hydrophobic compounds, and improve the specificity and efficiency of drug action. Their nanoscale size and modular functionality make them promising for the injectable, targeted and controlled delivery of various therapeutic agents and imaging probes into required cells. Additionally, cationic polyurethanes are able to self-assemble with nucleic acids into nanoparticles to enter cells for efficient gene transfection. These emerging nanocarriers open the door for addressing the failure of traditional localized delivery systems, and present a compelling future opportunity to achieve personalized therapy as versatile candidates. This review article highlights the research progress in the self-assembly of biodegradable polyurethanes for controlled delivery applications, with particular attention being paid to some representative vehicles such as self-assembled polyurethane micelles, nanogels, and polyurethane/DNA complexes, which have emerged as the focus of interest in recent years.

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Section: Self-assembled Polyurethane Nanogels As Injectable Drug Deli...mentioning

confidence: 99%

Self-assembly of biodegradable polyurethanes for controlled delivery applications

et al. 2012

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“…Polyurethane films possessing water contact angles below 90 °C are considered to be hydrophilic with increased wettability . The surface wettability of polyurethane films was determined by water contact angle measurements and the data for parent polyurethanes and click‐functionalized polyurethanes are summarized in Table and Table .…”

Section: Resultsmentioning

confidence: 99%

Clickable polyurethanes based on s‐triazine ring containing aromatic diisocyanate bearing pendent alkyne group: Synthesis and postmodification

Garg

Chatterjee

Wadgaonkar

2017

J. Polym. Sci. Part A: Polym. Chem.

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A new s-triazine ring containing aromatic diisocyanate bearing a pendent alkyne group, namely, 2,4-bis(4-isocyanatophenoxy)26-(prop-2-yn-1-yloxy)21,3,5-triazine was synthesized and reacted with various diols viz., 1,10-decanediol, tetraethylene glycol and polyethylene glycols in the presence of dibutyltin dilaurate as the catalyst to obtain a series of linear polyurethanes. The selected polyurethanes possessing pendent alkyne groups were postmodified with chemically diverse azides viz., 1-(azidomethyl)benzene, 1-(azidomethyl)pyrene, and methoxy end-caped poly(ethylene glycol) azide via coppercatalysed azide-alkyne Huisgen 1,3-dipolar cycloaddition. FTIR and 1 H NMR spectra indicated quantitative click reaction. UVvis and fluorescence spectroscopic analysis confirmed complete incorporation of pyrenyl groups indicating the formation of fluorescence active polyurethane by postmodification with 1-(azidomethyl)pyrene. TG analysis of polyurethanes indicated two stage weight loss and their thermal stability, as judged by T 10 values, was governed by weight percent of urethane linkages. The water contact angle measurements revealed improved wettability with increased content of PEG either in the backbone of polyurethanes or as grafted chains. DLS and TEM studies confirmed that certain polyurethanes possessing PEG segments displayed self-assembly in aqueous solution, which was further supported by pyrene encapsulation studies using UV-vis spectroscopy.

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“…The following bands were shown in this figure. NH and OH stretching bands (3267 cm ¡1 ), CH stretching (2945 cm ¡1 ), carbonyl stretching of IA and NHMAA (1649 cm ¡1 ), NH bending (for amides) (1536 cm ¡1 ), CH bending of -CH 2 CO-group (1447 cm ¡1 ), CH bending of -CH 2 -group (1381 cm ¡1 ), C-N stretching for amides (1273 cm ¡1 ), C-O stretching (1238 cm ¡1 ) and OH out-plane bending band (1013 cm ¡1 ) (1,22,23).…”

Section: Resultsmentioning

confidence: 99%

pH and Thermo Sensitive Superabsorbent Poly (N-Hydroxymethylacrylamide-co-Itaconic Acid) Hydrogels: Synthesis, Characterization and Kinetic Studies

Özdemir

Mazi²

2014

Journal of Macromolecular Science, Part A

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In this study, itaconic acid (IA) was co-polymerized with N-hydroxymethylacrylamide (NHMAA) by free radical solution polymerization to prepare pH and thermo sensitive superabsorbent hydrogels. The polymerization process was carried out at 25 C by using ammonium persulfate (APS) and N,N,N',N'-tetramethylethylenediamine (TMEDA) as initiating system and ethyleneglycoldimethacrylate (EGDMA) as a crosslinking agent. The effects of copolymer composition, crosslinking agent concentration, pH and temperature on swelling capacity and kinetic parameters were investigated. The copolymer hydrogels were characterized by using swelling studies and FT-IR analyses. The equilibrium degree of swelling of hydrogels was found to increase as pH value of the swelling solution varied from 2 to 12 and temperature from 45 to 25 C. The dynamic swelling studies have showed that, the diffusion exponent(n) and the diffusion coefficient(k) both increase with increasing content of itaconic acid.

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Syntheses and self-assembly of novel polyurethane–itaconic acid copolymer hydrogels

Cited by 16 publications

References 29 publications

Self-assembly of biodegradable polyurethanes for controlled delivery applications

Self-assembly of biodegradable polyurethanes for controlled delivery applications

Clickable polyurethanes based on s‐triazine ring containing aromatic diisocyanate bearing pendent alkyne group: Synthesis and postmodification

pH and Thermo Sensitive Superabsorbent Poly (N-Hydroxymethylacrylamide-co-Itaconic Acid) Hydrogels: Synthesis, Characterization and Kinetic Studies

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