Syntheses and Insecticidal Activity of Spirocyclic Tetronic Acid Derivatives Containing Oxime Ether Moiety

Spiro Derivatives in the Discovery of New Pesticides: A Research Review

“…68 In addition, compound 36 exhibited higher insecticidal activity against Tetranychus cinnabarinus even at a low concentration (0.046875 mg/L), 65 and compound 40 showed more than 95% insecticidal activity against Tetranychus cinnabarinus at 500 mg/L. 63 Compounds 34 and 35 demonstrated higher activity levels against Nilaparvata lugens than spirotetramat, 69 and compound 39 displayed 100% insecticidal activity against Plutella xylostella at 20 mg/L. 64 SARs analysis showed that the introduction of electron-withdrawing groups enhanced insecticidal activity, and their effects in the para-position were greater than in the ortho-position.…”

“…Despite these efficacies and positive effects, increasing drug-tolerance in pests necessitates the discovery of new and efficient insecticidal compounds. When studying the biological activity of spirotetramat derivatives, Cheng et al found that compounds 30 – 40 − exhibited remarkable insecticidal activities against Aphis fabae , Tetranychus cinnabarinus , and Nilaparvata lugens . Log P values below 6 were shown to be beneficial against insecticidal activity .…”

Recent Research Progress in Oxime Insecticides and Perspectives for the Future

“…In recent years, there has been growing interest in insecticides based on natural products, − such as nicotine, pyrethrum, and neem extracts, which are extracted directly from plants and utilized for pest control Figure illustrates some representative natural products of oxime ether with insecticidal activity.…”