Syntheses and electronic, electrochemical, and theoretical studies of a series of μ-oxo-triruthenium carboxylates bearing orthometalated phenazines

Abstract

Phenazines orthometalation in [Ru3(μ3-O)(μ-OAc)5{μ-η1(C),η2(N,N)-L}(py)2]PF6 clusters provides new DNA metalo-intercalators. fsTA for such compounds is presented for the first time.

A novel triruthenium nitrosyl bearing a quinolinic ligand: a comparison of its spectroscopic behavior with its pyridine analogues

“…64 The pK a is a good parameter to rationalize the properties of triruthenium compounds since the basicity of the ligands modulates the electronic density of the metallic core via s-donation. 6,17,20,38,39 By analogy with the studies mentioned above, we tried to verify patterns in the behavior of trinuclear ruthenium nitrosyl compounds by using the spectroscopic data set summarized in Table 2, and we attempted to correlate them with the pK a of the ligands in the investigated series. Fig.…”

“…Only a few studies on this last topic are available, including anticancer and trypanocidal activities [11][12][13][14] and their interactions with HSA (human serum albumin) 15 and DNA. 16 The ability of these compounds to perform photoinduced processes like electron-transfer reactions [17][18][19] or the photoinduced release of active molecules is relevant to this work. Triangular m-oxo triruthenium compounds are useful for the controlled delivery of carbon [20][21][22] and nitric monoxides, 23,24 which has led us to explore the potential of these systems to act as biologically active photoNORMs (NO-releasing molecules).…”

Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium(ii) complexes

“…1f ). This higher pK a value in comparison to free dppz ( pK a = 3.35) 53 can be explained by the π-back-bonding effect of Ru(II), which electronically enriches N-heterocyclic aromatic ligands. Furthermore, we observed a second process assigned to the nitrosyl/nitro interconversion occurring at pH 9.16.…”

“…The equilibrium constant was determined for nitro-nitrosyl ligands using spectroscopic measurements in the UV-vis region of the PR02 compound following the methodology described in the literature. 53 Initially, PR02 was prepared at a concentration of 40 μmol L −1 and dissolved in a 0.1 mol L −1 of HTFA solution, which was titrated with NaOH. All spectroscopic changes were collected at each pH using a pH meter (model 827 Metrohm).…”