Syntheses and DNA-binding studies of two ruthenium(II) complexes containing one ancillary ligand of bpy or phen: [Ru(bpy)(pp[2,3]p)2](ClO4)2 and [Ru(phen)(pp[2,3]p)2](ClO4)2

pH- and DNA-induced dual molecular light switches based on a novel ruthenium(II) complex

“…Although the additions of ct-DNA can induce the photoluminescence enhancements of [Ru(bpy) 2 (taptp)] 2+ and [Ru(phen) 2 (taptp)] 2+ (taptp = 4,5,9,18-tetraazaphenanthreno [9,10-b] triphenylene), but the phen-containing complex has a negligible luminescence in DNAfree water buffer contrast to the strong luminescence for the bpy-containing complex [34]. Recently, We have reported acidbase and/or DNA binding properties of a series of polypyridyl Ru(II) complexes [5,[35][36][37][38]. However, to the best of our knowledge, dual-functional Ru(II) complexes featuring with pH and DNA-induced luminescent molecular switches have been very limited [7,38].…”

Crystal structure and biological activities of water-soluble nickel(II) and copper(II) complexes of a Schiff-base derived from paeonol

“…Therefore, the interaction of metal complexes with DNA has attracted much attention. During the past decade, a large number of Ru(II) complexes have been synthesized, and the interactions of these complexes with DNA have been intensively studied [18][19][20][21]. Although Ru(II) complexes are relatively stable and also have useful spectroscopic properties, their limited solubility is a severe limitation on their application in biological systems.…”

Synthesis, crystal structure and DNA-binding studies of a Ru(II) complex containing two main ligands

“…However, the Ru(II) complexes with one ancillary ligand and two main ligands have attracted a spot of front attention this century [8][9][10][11][12]. Varying the number of main ligands can create some interesting differences in the space configuration and the electron-density distribution of Ru(II)-polypyridyl complexes, which will result in differences in spectral properties and the DNA-binding behaviors of these complexes, and may serve to more clearly understanding of the DNA-binding mechanism.…”

“…The concentration of [Ru(bpy)(dppz) 2 ] 2+ to make the DNA convert to form II completely is 40 lM under the same condition. At the same time, the title complex exhibit more effective cleavage activity comparing to the complex [Ru(phen)(ppd) 2 ] 2+ (ppd = pteridino[6,7-f] [1,10]phenanthroline-11,13(10H,12H)-dione) which contains two main ligands, too [12]. Although the mechanism is not clear, it is also important since the increasing of the charge of the ancillary ligand can enhance the cleavage activity of the complex with supercoiled DNA.…”

“…For example, [Ru(bpy) 2 (dppz)] 2+ (dppz = dipyrido[3,2-a:2 0 ,3 0 -c]phenazine]) has shown high affinity (K b > 10 6 ) [4], since the dppz ligand possess extended planar p-aromatic structures, which can insert and stack between the base-pairs of double helical DNA [5][6][7]. However, the Ru(II) complexes with one ancillary ligand and two main ligands have attracted a spot of front attention this century [8][9][10][11][12]. Varying the number of main ligands can create some interesting differences in the space configuration and the electron-density distribution of Ru(II)-polypyridyl complexes, which will result in differences in spectral properties and the DNA-binding behaviors of these complexes, and may serve to more clearly understanding of the DNA-binding mechanism.…”