Syntheses and applications of periodic mesoporous organosilica nanoparticles

Abstract

Periodic Mesoporous Organosilica (PMO) nanomaterials are envisioned to be one of the most prolific subjects of research in the next decade. Similar to mesoporous silica nanoparticles (MSN), PMO nanoparticles (NPs) prepared from organo-bridged alkoxysilanes have tunable mesopores that could be utilized for many applications such as gas and molecule adsorption, catalysis, drug and gene delivery, electronics, and sensing; but unlike MSN, the diversity in chemical nature of the pore walls of such nanomaterials is theoretically unlimited. Thus, we expect that PMO NPs will attract considerable interest over the next decade. In this review, we will present a comprehensive overview of the synthetic strategies for the preparation of nanoscaled PMO materials, and then describe their applications in catalysis and nanomedicine. The remarkable assets of the PMO structure are also detailed, and insights are provided for the preparation of more complex PMO nanoplatforms.

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

“…[31][32][33][34][35][36] MSN are promising nanoplatforms for nanobiomedicine due to their biocompatibility, high specific surface areas, tunable pore sizes, and known silicon chemistry. [37] Silica NPs are slowly degraded in water by dissolution into biocompatible and bioadsorbed silicic acid products, [38] and silica NPs are renally excreted. [39][40][41] The unique properties of MSN and silica hybrid NPs have been implemented in catalysis, [37,42] separation, [43][44][45] bio-imaging, [33,[46][47][48] and in cargo delivery applications, [34][35][36][37][49][50][51] to name a few.…”

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging

“…Among recent developments in the area of smart nanomaterials, [3,[23][24][25] mesoporous silica nanoparticles (MSN) have attracted much attention as one of the most promising nanoplatforms for nanomedicine. [26][27][28][29][30][31][32][33][34] MSN are biocompatible nanomaterials [35,36] and possess disctinctive characteristics such as their tunable porosity and particle size, versatile inner and outer surface chemistry, and capacity to transport and deliver various cargos make these scaffolds ideal drug delivery systems.…”

“…[1][2][3] Indeed, many cancer chemotherapeutic treatments still face low efficacies and failure despite tremendous financial investments of companies and governements. One of the main causes for this major societal concern is the lack of selectivity of anticancer drugs towards cancer tissues, leading to severe side effects on healthy tissues and eventually the death of patients.…”

Colloidal Mesoporous Silica Nanoparticles

“…161 Furthermore, the use of bridged organosiloxanes with aromatic groups tends to lead to the formation of mesoporous materials with crystalline structures, 15 though there are no reports on the preparation of nanosized mesoporous organosiloxane nanoparticles with crystalline structures. A recent publication by Croissant et al 169 is useful for preparative methods and applications of noncolloidal mesoporous organosiloxane nanoparticles.…”