Syntheses and antimicrobial activities of amide derivatives of 4-[(2-isopropyl-5-methylcyclohexyl)oxo]-4-oxobutanoic acid

Abstract

ABSTRACT

New efficient synthesis, spectroscopic characterization, and X-ray analysis of novel β-enaminocarboxamide derivatives

“…In addition, the amide group (CONH 2 ) has an important place in medicinal chemistry as an efficient pharmacophore and constitutes an integral part in many synthetic and natural active compounds [20][21][22][23]. These derivatives have shown interesting therapeutic properties such as: anticonvulsant [24], antitubercular [25], antimicrobial [26], analgesic and anti-inflammatory [27], insecticide [28], anticancer [29], fibrinolytic [30], nootropic [31], and antihypertensive [32] (Fig. 2).…”

Synthesis of carboxamide and sulfonyl carboxamide linked heterocycles under green conditions

“…Amide moiety represents a privileged structural motif and it plays an important role in the composition of polymers, proteins, natural products and pharmaceuticals. 1,2 Various approaches were explored for efficient construction of this significant skeleton. 3,4 The most common synthetic route relies on the reactions of activated carboxylic acids and their derivatives with amines.…”