Synthesen von Antibiotica‐Zuckern

Brimacombe, J. S.

doi:10.1002/ange.19710830802

Cited by 21 publications

(1 citation statement)

References 61 publications

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“…To our knowledge tricycles of this kind containing a pyranosidic ring system anellated to an aromatic ring in 1-and 2-position over a NHfunction are not yet described in the literature. The corresponding 5-amino-2-methyl-6-(2-nitro-phenyl)-4-phenyl(2-furyl)tetrahydropyranols are interesting owing to the biological activity of a variety of 5-amino-tetrahydro-2-pyranols [2][3][4]. Although there are many literature methods for conversion of a aliphatic nitro group into an amino function the 5-amino-tetrahydro-2-pyranol could not be obtained, neither by means of reducing agents like Zn/hydrochloric acid nor by refluxing with LiAlH 4 in tetrahydrofuran [5].…”

Section: Resultsmentioning

confidence: 99%

Heterocyclic Tricycles as Internal N-Glycosides from 2-Methyl-5-nitro-6-(2-nitrophenyl)-4-phenyl(2-furyl)tetrahydropyranols

et al. 2000

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1-Methyl-10-nitro-11-phenyl(2-furyl)-2-aza-13-oxa-tricyclo[7.3.1.0 3,8 ]trideca-3,5,7-trienes 3 were synthesized via the reduction of the aromatic 2-nitro group of 2-methyl-5-nitro-6-(2-nitrophenyl)-4-phenyl(2-furyl)tetrahydropyranols 2 and subsequent condensation with their anomeric OH group. As by-products, the corresponding 6-(2-aminophenyl)-2-methyl-5-nitro-4-phenyl(2-furyl)tetrahydropyranols 4 were isolated.

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Section: Resultsmentioning

confidence: 99%

Heterocyclic Tricycles as Internal N-Glycosides from 2-Methyl-5-nitro-6-(2-nitrophenyl)-4-phenyl(2-furyl)tetrahydropyranols

et al. 2000

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Antibiotics

Ohno¹,

Otsuka²,

Okamoto³

et al. 2008

Ullmann's Encyclopedia of Industrial Chemistry

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Antibiotics, 1. General

Ohno

Otsuka

Okamoto

et al. 2011

Ullmann's Encyclopedia of Industrial Chemistry

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Antibiotics can be defined as chemical substances capable of inhibiting the growth of microorganisms. In the past decades, numerous compounds possessing various biological activities have been discovered. Antibiotics can be of microbial origin, semisynthic, or totally synthetic. Their classification is based mostly on structural characteristics. This article gives a comprehensive overview of the classes of antibiotica. The article contains sections titled: 1. Introduction 1.1. General Definition 1.2. Historical Development and Classification 1.3. Nomenclature 2. Chemotherapeutic Use of Antibiotics 2.1. Microbial Pathogens 2.2. Tumor Cells 2.3. Chemotherapeutic Uses 2.4. Use in Agriculture 2.5. Units 2.6. Analysis 3. Classification of Antibiotics 3.1. β‐Lactams 3.1.1. Natural Penicillins 3.1.2. Semisynthetic Penicillins 3.1.3. Natural Cephalosporins 3.1.4. Semisynthetic Cephalosporins 3.1.5. Cephamycins 3.1.6. 1‐Oxacephems 3.1.7. β‐Lactamase Inhibitors 3.1.8. Penems 3.1.9. Carbapenems 3.1.10. Monocyclic β‐Lactams 3.2. Tetracyclines 3.3. Anthracyclines 3.4. Aminoglycosides 3.5. Nucleosides 3.5.1. N ‐Nucleosides 3.5.2. C ‐Nucleosides 3.5.3. Carbocyclic Nucleosides 3.6. Macrolides 3.6.1. 12‐Membered Ring Macrolides 3.6.2. 14‐Membered Ring Macrolides 3.6.3. 16‐Membered Ring Macrolides 3.6.4. Polyenes 3.7. Ansamycins 3.8. Peptides 3.9. Enediyne 3.10. Other Important Antibiotics 4. Antibiotic Resistance

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Synthesen von Antibiotica‐Zuckern

Cited by 21 publications

References 61 publications

Heterocyclic Tricycles as Internal N-Glycosides from 2-Methyl-5-nitro-6-(2-nitrophenyl)-4-phenyl(2-furyl)tetrahydropyranols

Heterocyclic Tricycles as Internal N-Glycosides from 2-Methyl-5-nitro-6-(2-nitrophenyl)-4-phenyl(2-furyl)tetrahydropyranols

Antibiotics

Antibiotics, 1. General

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