Synthese und virustatische wirksamkeit von n'-substituierten n- [adamantyl-(2)]-thioharnstoffen

Kreutzberger, A.; Schröders, Hans-Helmut

doi:10.1016/s0040-4039(00)72434-8

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Inf Luenza A: the Amantadine And Rimantadine Story1

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1973

2013

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“…132 In in vitro tests, some adamantyl thioureas furthermore showed activity against a number of other viruses. 133 Since some of the adamantyl thioureas have proven active in vivo at low toxicity, a small library of nine 3-substituted 1-adamantylthioureas was synthesized and quantitative antiviral activities for three of them in mice challenged with the Inf luenza A 2 (Asian)/J305 strain. 134 Compound 61 was shown to compare favorably with amantadine with respect to both activity and toxicity.…”

Section: Inf Luenza A: the Amantadine And Rimantadine Storymentioning

confidence: 99%