Synthese und biologische Aktivität von D‐3‐Desoxy‐3‐fluorphosphatidylinosit, ein neuer Weg zu nicht auf DNA zielenden Cytostatica

Amides of Trivalent Phosphorus Acids as Phosphorylating Reagents for Proton-Donating Nucleophiles

“…Oxidation and deprotection (usually catalytic hydrogenolysis) give the desired phosphates in high yields. In addition, methods for the synthesis of inositol phosphites containing deoxy units, tritium, fluorine, and phytoactive groups have also been reported in the literature. Inositol phosphites were made to react with sulfur, which allowed the synthesis of the corresponding phosphorothioates, recommended as inhibitors of some enzymatic reactions …”

“…Phosphorylation of pentakis-protected inositols by equimolar amounts of phosphorus diamides made it possible to synthesize inositol phosphoramidites. Subsequently, these products can be used to phosphorylate other biological molecules, for example, see Scheme 70 …”

“…Subsequently, these products can be used to phosphorylate other biological molecules, for example, see Scheme 70. 330 Yet another route to this type of complex lipid diphosphites consists of the phosphorylation of protected inositol by lipophosphoramidites. 318,328,[331][332][333] Phosphorylated steroids and higher fused terpenoids can also be placed among the large class of phospholipids.…”