Synthèse et greffage de polymères bioactifs sur des surfaces en titane pour favoriser l’ostéointégration

Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry

“…This result confirms the tendency found in several studies that the osteoblastic differentiation is favored by anodized surfaces [4,11,37]. The enzymatic activity after 14 days is also significantly higher in group C than in any other studied group, once again this increase has been documented in the literature [18,25] As expected, given the ALP results, surfaces of the group C present statistically superior mineralization than the other surface groups for both markers (p < 0.05). The difference is even more prominent after 28 days, indicating larger osteoblast maturation.…”

“…In addition to improving in vitro calcium-phosphate deposition [17,18] and in vivo bone formation [19,20], such treatment can play an inhibitory role on bacterial adhesion for both gram positive and negative strains [21,22]. It was found that the adhesion of bacteria to pNaSS grafted surfaces in the presence of pure or diluted blood plasma and of different protein solutions are strongly influenced by the presence of sulfonate groups in the macromolecular chains of the grafted polymer [23].…”

Le greffage radicalaire de polymères bioactifs sur le titane pour prévenir l’infection sur prothèse articulaire

“…Pour amorcer la réaction de polymérisation, il est nécessaire de créer des radicaux libres sur la surface du maté-riau. Un mélange d'une solution aqueuse d'acide sulfurique et de peroxyde d'hydrogène est réalisé dans les proportions 50/50 (v/v), afin de créer par oxydation chimique de l'échantillon des groupements d'hydroperoxide [7,8]. L'optimisation des conditions de greffages a fait l'objet de la thèse de Dr Mayingi [7].…”

Structural, Morphological, and Electrochemical Corrosion Properties of TiO2 Formed on Ti6Al4V Alloys by Anodization

“…The adopted approach to improve the osteointegration was to modify the metal surfaces by means of different techniques inducing more efficiency in the implant/bone interface, such as a chemical functionalization and anodizing . The later has been extensively applied for titanium and its alloys.…”