Synthese des verzweigten Tetrasaccharid-Bausteins der Schlüsselsequenz 152 von N-Glycoproteinen

Strategies of Synthetic Methodologies for Constructing β-Mannosidic Linkage

“…The trisaccharide 32a was accompanied with 23% recovered acceptor [47][48][49] The use of the insoluble silver zeolite promoter in glycosylation methods showed improved yields in preparation of β-D-mannopyranosides. Thus, a series of mannosides 33 were prepared via reaction of mannosyl bromide 2 4 with alcohol and silver zeolite in dichloromethane or toluene at room temperature for few hours to overnight.…”

Synthesis of Diverse Asparagine Linked Oligosaccharides and Synthesis of Sialylglycopeptide on Solid Phase

“…For the β-mannosyl linkages, in 1982, Paulsen reported that the β-mannosyl linkage can directly be formed by use of silver silicate [7] and then in 2001, Crich reported a facile synthesis of direct β-mannosyl linkage formation [8]. Hindsgaul [9], Stork [10] and Ito [11] reported a sophisticated β -mannosylation reaction in which an oligosaccharide acceptor was tethered at the 2-position of the mannosyl donor, and then β -mannosylation stereospecifically occurred.…”

Chemical Synthesis of Asparagine‐Linked Glycoprotein Oligosaccharides: Recent Examples

“…Paulsen exploited "insoluble" Ag salt (silver silicate) for the problematic b-manno glycoside formation (Scheme 9.7) [22]. 3,6-O-Allyl-2,4-O-benzyl-mannosyl bromide 8 was treated with the acceptor 9 to provide b-linked product 10 [23].…”