Synthèse des recommandations de l’International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) sur le suivi thérapeutique pharmacologique du tacrolimus

Lemaître, F.; Monchaud, Caroline; Woillard, Jean‐Baptiste; Picard, Nicolas; Marquet, Pierre

doi:10.1016/j.therap.2020.06.004

Cited by 6 publications

(2 citation statements)

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“…Therefore, instead of using C 0 alone to guide tacrolimus therapy, it is now recommended to use both the C 0 and AUC 0–12 for recipient management, at least once within the early period after transplantation and at another time within the stable phase. 38 …”

Section: When Is Tdm Most Beneficial?mentioning

confidence: 99%

“…For tacrolimus, another widely used calcineurin inhibitor (i.e., a drug that inhibits the T‐cells of the immune system), it was found that patients with identical C 0 may have very different AUC 0–12h , which explains differences in treatment efficacy. Therefore, instead of using C 0 alone to guide tacrolimus therapy, it is now recommended to use both the C 0 and AUC 0–12 for recipient management, at least once within the early period after transplantation and at another time within the stable phase 38 …”

Section: When Is Tdm Most Beneficial?mentioning

confidence: 99%

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Utility, promise, and limitations of liquid chromatography‐mass spectrometry‐based therapeutic drug monitoring in precision medicine

et al. 2021

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Therapeutic drug monitoring (TDM) is typically referred to as the measurement of the concentration of drugs in patient blood. Although in the past, TDM was restricted to drugs with a narrow therapeutic range in order to avoid drug toxicity, TDM has recently become a major tool for precision medicine being applied to many more drugs. Through compensating for interindividual differences in a drug's pharmacokinetics, improved dosing of individual patients based on TDM ensures maximum drug effectiveness while minimizing side effects. This is especially relevant for individuals that present a particularly high intervariability in pharmacokinetics, such as newborns, or for critically/severely ill patients. In this article, we will review the applications for and limitations of TDM, discuss for which patients TDM is most beneficial and why, examine which techniques are being used for TDM, and demonstrate how mass spectrometry is increasingly becoming a reliable and convenient alternative for the TDM of different classes of drugs. We will also highlight the advances, challenges, and limitations of the existing repertoire of TDM methods and discuss future opportunities for TDM‐based precision medicine.

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Section: When Is Tdm Most Beneficial?mentioning

confidence: 99%

Section: When Is Tdm Most Beneficial?mentioning

confidence: 99%