Synthèse de substrats indigogéniques. Mise en évidence de l'activité estérasique des Salmonella

Agban, Amégninou; Ounanian, M; Luu‐Duc, C.; Monget, D.

doi:10.1016/0223-5234(90)90135-p

Cited by 2 publications

(2 citation statements)

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“…It is also used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids and as a reference compound in enzyme assay [6]. Synthesis of new fluorogenic substrates derived from 7-amino-4-trifluoromethyl coumarin are helpful to detect streptococci and euterococci [7]. Some coumarin derivatives are found to have anticancer [8,9], diuretic, analgesic, myorelaxant [10], antifungal [11] and anthelmintic [12] properties.…”

Section: Introductionmentioning

confidence: 99%

Molecular structure, vibrational spectroscopic studies and natural bond orbital analysis of 7-amino-4-trifluoromethyl coumarin

2010

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Quantum mechanical calculations of energies, geometries and vibrational wave numbers of 7-amino-4-trifluoromethyl coumarin (7A4TFMC) were carried out using Hartree-Fock (HF) and density functional theory (DFT) using hybrid functional BLYP and B3LYP with 6-31G(d,p) as basis set. The optimized geometrical parameters obtained by HF and DFT calculations are in good agreement with the experimental X-ray data. The best method to reproduce the experimental wave numbers is B3LYP method with the 6-31G(d,p) basis set. The difference between the observed and scaled wave number values of most of the fundamentals is very small. A detailed interpretation of the infrared spectra of 7A4TFMC was also reported. The entropy of the title compound was also performed at HF using the hybrid functional BLYP and B3LYP with 6-31 G(d,p) as basis set levels of theory. Natural bond orbital (NBO) analysis of the title molecule is also carried out. The theoretical spectrogram for FTIR spectra of the title molecule has been constructed.

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Section: Introductionmentioning

confidence: 99%

Molecular structure, vibrational spectroscopic studies and natural bond orbital analysis of 7-amino-4-trifluoromethyl coumarin

2010

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“…5-Bromo-4-chloro-3-indolylderivates or p-nitrophenyl substrates are well established examples [9,10]. Another useful means of analysis of many samples in parallel is IR spectroscopy, which has been used to analyse a biotransformation with lipase, with high throughput [11].…”

Section: Introductionmentioning

confidence: 99%

High-throughput assay of ( R )-phenylacetylcarbinol synthesized by pyruvate decarboxylase

Breuer¹,

Pohl²,

Hauer³

et al. 2002

Analytical and Bioanalytical Chemistry

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A novel assay has been developed for the detection of ( R)-phenylacetylcarbinol, ( R)-PAC, a chiral intermediate in the industrial synthesis of ephedrine. It is the product of a biotransformation of benzaldehyde catalysed by the enzyme pyruvate decarboxylase. The assay, using 2,3,5-triphenyltetrazolium chloride, enables high-throughput photometric analysis of the activity of the enzyme thus avoiding time-consuming chromatographic procedures.

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Synthèse de substrats indigogéniques. Mise en évidence de l'activité estérasique des Salmonella

Cited by 2 publications

References 4 publications

Molecular structure, vibrational spectroscopic studies and natural bond orbital analysis of 7-amino-4-trifluoromethyl coumarin

Molecular structure, vibrational spectroscopic studies and natural bond orbital analysis of 7-amino-4-trifluoromethyl coumarin

High-throughput assay of ( R )-phenylacetylcarbinol synthesized by pyruvate decarboxylase

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