Synthese de nouvelles 1H,3H pyrido[2,3‐d] pyrimidinediones‐2,4

Abstract

Dans cet article les auteurs décrivent la synthèse et les propriétés physico‐chimiques de nouvelles pyrido[2,3‐d]pyrimidinediones‐2,4 mono ou disubstituées.

Synthesis and Spectroscopic Properties of Quinazolinedione Derivatives

“…Quinazoline-2,4(1H,3H)-dione 2 was prepared by fusing anthranilic acid and urea at 140-150ºC in low yield (30%) [21] . However using potassium cyanate method provide higher yield (82%) [22] .…”

Six‐Membered Heterocycles: Triazines, Tetrazines and Other Polyaza Systems

“…Treatment of 1,2,4-triazines and their 3-oxo derivatives with reducing agents such as Raney nickel, sodium borohydride, titanium(III) chloride, hydrogen and palladium catalyst, or electrochemical reduction affords dihydro and further tetrahydro-1,2,4-tetrazine derivatives [290,310,394,395]. In the case of oxo derivatives reduction occurs in the triazine ring, affording dihydrotriazinones that can further yield tetrahydotriazinones or imidazoles [395,396].…”

“…In the case of oxo derivatives reduction occurs in the triazine ring, affording dihydrotriazinones that can further yield tetrahydotriazinones or imidazoles [395,396].…”

A simple synthesis of aminopyridines: use of amides as amine source

“…2 Substituted or unsubstituted aminopyridines are also useful precursors for the synthesis of a variety of heteocyclic compounds possessing a medicinal value. [3][4][5][6][7][8][9] For example, 2-(methylamino)nicotinonitrile or 2-amino-3-nitropyridine was used as a synthetic precursor of 1H,3H-pyrido [2,3-d]pyrimidine-2,4-dione 10 or pyrido [2,3-b] pyrazines 11 and imidazo [4,5-b]pyridines 12 respectively.…”