Syntesis and characterization of zein nanoparticles loaded with essential oil of <i>Ocimum gratissimum</i> and <i>Pimenta racemosa</i>

Melo, Ana Paula Zapelini de; Rosa, Cleonice Gonçalves da; Nunes, Michael Ramos; Noronha, Carolina Montanheiro; Maciel, Matheus Vinícius de Oliveira Brisola; Villetti, Marco Antônio; Bertoldi, Fabiano Cleber; Barreto, Pedro Luiz Manique

doi:10.1088/2053-1591/ab2fc1

Cited by 15 publications

(2 citation statements)

References 32 publications

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“…The chemical characterization of the thyme essential oil was realized by Gas Chromatography coupled with Mass Spectrometry detector (GC/MS) (Shimadzu, model GC/MS QP 2010). The chromatography conditions of GC/MS were based on de Melo et al [13], with modifications. Was used a Capillary column ZB-5MS, 30 m×0.25 mm×0.25 μm film, a injector in temperature of 250°C, helium gas flow of 1 ml min −1 .…”

Section: Methodsmentioning

confidence: 99%

Antibacterial activity, morphology, and physicochemical stability of biosynthesized silver nanoparticles using thyme (Thymus vulgaris) essential oil

Melo

Maciel

Almeida

et al. 2020

Mater. Res. Express

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Considering the importance of biosynthesized silver nanoparticles (AgNPs) using plant phytochemicals, the aim of this work was to evaluate the effect of pH in the formulation of AgNPs, bioreduced with thyme essential oil. Biosynthesized AgNPs were prepared under different pH (7, 8, 9 and 10), and the physicochemical stability was evaluated during 90 days at 6°C and 25°C. Using GC/MS technique, 17 different compounds were observed in the thyme essential oil; however, borneol and αterpineol were the majoritarian compounds, probably responsible to the formation of AgNPs. UV-vis spectroscopy with absorbance between 415 and 440 nm and Transmission Electron Microscopy (TEM) confirmed the synthesis of nanoparticles, with diameters of 40 nm and spherical shapes to pH 7, 8 and 9. Through DLS approach, was observed that the average particle diameter was around 90 nm for all pH tested. AgNPs presented homogeneous size distribution, and zeta potential values very close to the theoretical stability range. Moreover, biosynthesized AgNPs presented high antibacterial activity against Escherichia coli and Staphylococcus aureus. Through x-ray Photoelectron Spectroscopic (XPS) analysis was possible confirm the presence of crystalline silver nanoparticles. Thus, silver nanoparticles eco-friendly prepared using thyme essential oil can be considered as an alternative way to produce this nanomaterial with great stability and high antibacterial activity.

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Section: Methodsmentioning

confidence: 99%

Antibacterial activity, morphology, and physicochemical stability of biosynthesized silver nanoparticles using thyme (Thymus vulgaris) essential oil

Melo

Maciel

Almeida

et al. 2020

Mater. Res. Express

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“…Recent findings again prompt that EOs can function in a synergistic combination with antifungals [ 21 , 22 ]. Regarding the delivery of EOs, in the last decade, polymeric nanoparticles have been extensively investigated as a controlled release systems for different hydrophobic substances [ 23 , 24 , 25 , 26 , 27 ]. Moreover, nano-encapsulation of bioactive compounds of EOs introduces several advantages such as the protection from the external environment, the improvement of the stability and bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Study of the Chemical Profile and Anti-Fungal Activity against Candida auris of Cinnamomum cassia Essential Oil and of Its Nano-Formulations Based on Polycaprolactone

Rosato

Napoli

Granata

et al. 2023

Plants

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Background: Candida auris represents an emerging pathogen that results in nosocomial infections and is considered a serious global health problem. The aim of this work was to evaluate the in vitro antifungal efficacy of Cinnamomum cassia essential oil (CC-EO) pure or formulated in polycaprolactone (PCL) nanoparticles against ten clinical strains of C. auris. Methods: nanoparticles of PCL were produced using CC-EO (nano-CC-EO) and cinnamaldehyde (CIN) through the nanoprecipitation method. The chemical profile of both CC-EO and nano-CC-EO was evaluated using SPME sampling followed by GC-MS analysis. Micro-broth dilution tests were performed to evaluate both fungistatic and fungicidal effectiveness of CC-EO and CIN, pure and nano-formulated. Furthermore, checkerboard tests to evaluate the synergistic action of CC-EO or nano-CC-EO with micafungin or fluconazole were conducted. Finally, the biofilm disrupting activity of both formulations was evaluated. Results: GC-MS analysis shows a different composition between CC-EO and nano-CC-EO. Moreover, the microbiological analyses do not show any variation in antifungal effectiveness either towards the planktonic form (MICCC-EO = 0.01 ± 0.01 and MICnano-CC-EO = 0.02 ± 0.01) or the biofilm form. No synergistic activity with the antifungal drugs tested was found. Conclusions: both CC-EO and nano-CC-EO show the same antimicrobial effectiveness and are potential assets in the fight against C. auris.

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Essential Oils from Plants and Their Role in Nanomaterial Synthesis Characterization and Applications

Maddala

Singh²

2023

Secondary Metabolites Based Green Synthesis of Nanomaterials and Their Applications

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Syntesis and characterization of zein nanoparticles loaded with essential oil of Ocimum gratissimum and Pimenta racemosa

Cited by 15 publications

References 32 publications

Antibacterial activity, morphology, and physicochemical stability of biosynthesized silver nanoparticles using thyme (Thymus vulgaris) essential oil

Antibacterial activity, morphology, and physicochemical stability of biosynthesized silver nanoparticles using thyme (Thymus vulgaris) essential oil

Study of the Chemical Profile and Anti-Fungal Activity against Candida auris of Cinnamomum cassia Essential Oil and of Its Nano-Formulations Based on Polycaprolactone

Essential Oils from Plants and Their Role in Nanomaterial Synthesis Characterization and Applications

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