Synteny mapping of the bovine IGHG2, CRC and IGF1 genes

Miller, Jim; Thomsen, Preben D.; Dixon, S. C.; Tucker, Elizabeth M.; Konfortov, B. A.; Harbitz, I.

doi:10.1111/j.1365-2052.1992.tb00231.x

Cited by 21 publications

(6 citation statements)

References 17 publications

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“…The activity of this gene in the adipose tissue and the subsequent increase in deposition of triglycerides are promoted by insulin [43]. Some studies have suggested that the FAs synthesis in the subcutaneous adipose tissue on beef is not sensitive to insulin levels [44, 45]. In this sense, the activity of LPL gene in the muscle tissue appears not to be insulin dependent [43], however, many authors have provided evidence to support the opposite [46, 47].…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile of intramuscular muscle in Nellore cattle with extreme values of fatty acid

et al. 2016

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BackgroundFatty acid type in beef can be detrimental to human health and has received considerable attention in recent years. The aim of this study was to identify differentially expressed genes in longissimus thoracis muscle of 48 Nellore young bulls with extreme phenotypes for fatty acid composition of intramuscular fat by RNA-seq technique.ResultsDifferential expression analyses between animals with extreme phenotype for fatty acid composition showed a total of 13 differentially expressed genes for myristic (C14:0), 35 for palmitic (C16:0), 187 for stearic (C18:0), 371 for oleic (C18:1, cis-9), 24 for conjugated linoleic (C18:2 cis-9, trans11, CLA), 89 for linoleic (C18:2 cis-9,12 n6), and 110 genes for α-linolenic (C18:3 n3) fatty acids. For the respective sums of the individual fatty acids, 51 differentially expressed genes for saturated fatty acids (SFA), 336 for monounsaturated (MUFA), 131 for polyunsaturated (PUFA), 92 for PUFA/SFA ratio, 55 for ω3, 627 for ω6, and 22 for ω6/ω3 ratio were identified. Functional annotation analyses identified several genes associated with fatty acid metabolism, such as those involved in intra and extra-cellular transport of fatty acid synthesis precursors in intramuscular fat of longissimus thoracis muscle. Some of them must be highlighted, such as: ACSM3 and ACSS1 genes, which work as a precursor in fatty acid synthesis; DGAT2 gene that acts in the deposition of saturated fat in the adipose tissue; GPP and LPL genes that support the synthesis of insulin, stimulating both the glucose synthesis and the amino acids entry into the cells; and the BDH1 gene, which is responsible for the synthesis and degradation of ketone bodies used in the synthesis of ATP.ConclusionSeveral genes related to lipid metabolism and fatty acid composition were identified. These findings must contribute to the elucidation of the genetic basis to improve Nellore meat quality traits, with emphasis on human health. Additionally, it can also contribute to improve the knowledge of fatty acid biosynthesis and the selection of animals with better nutritional quality.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3232-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Gene expression profile of intramuscular muscle in Nellore cattle with extreme values of fatty acid

et al. 2016

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“…Long-term use of recombinant GH in dairy farms has confirmed the key role of the somatotrophic axis in this physiological function (Bauman, 1999;Baldi, 1999). IGF-I is a well-known somatomedin (Sorensen et al, 1992;Renaville, 1997;Curi et al, 2005); it is expressed by a gene located on chromosome 5 that shows an SnaBI polymorphysm in the 5' flanking region (Miller et al, 1992;Ge et al, 1997). Parmentier et al (1999) reviewed the somatotrophic axis and its relationship with milk production and selection; this pathway and particularly IGF-I, the 7649-Da single-chain peptide and its gene, appear to be promising for association with reproductive traits in Angus beef cattle (Yilmaz et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows

Bonakdar¹,

Rahmani²,

Edriss³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. We estimated the allele and genotype frequencies of IGF-I/SnaBI gene polymorphism and the concentration of this protein in Holstein dairy cows. We also examined the association with milk yield (305-day milk yield) and milk components (fat and protein percentage, and 305-day milk protein and fat yield). Blood IGF-I levels were measured and genotyping was performed on 250 Holstein cows of four different herds. In the association studies, traits of interest were analyzed using the GLM procedure of SAS; means of the IGF-I level among genotypes were compared by the LSMeans test. The AB and AA genotypes were the most (0.583-0.661) and least (0.083-0.192) frequent in the herds, respectively; the frequency of the BB genotype ranged from 0.201 to 0.333. The frequency of the A allele ranged from 0.375 to 0.495, while the frequency of the B allele ranged from 0.504 to 0.625, being the dominant allele. The mean level of IGF-I was 107 ± 22 ng/mL for all groups, without IGF-I gene and milk components any significant correlation with the production traits. Association of IGF-I/SnaBI genotypes with percentage of fat and protein in the milk was relatively high (P < 0.1 and P < 0.05, respectively); the AB genotype was superior to AA and BB genotypes. We concluded that this marker should be considered for milk component selection in Holstein dairy cattle.

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“…Bovine insulin-like growth factor 1 (IGF1) gene is localized in chromosome 5 and consists of 6 exons (Bishop et al, 1991;Miller et al, 1992). IGF1 has been shown to be a candidate gene for growth rate and meat production traits due to its role in regulation of cell proliferation and animal growth (Siadkowska et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Relationship of the bovine IGF1, TG, DGAT1 and MYF5 genes to meat colour, tenderness and cooking loss

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et al. 2018

J Hellenic Vet Med Soc

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Bovine insulin-like growth factor 1 (IGF1), thyroglobulin (TG), diacylglycerol-O-acyltransferase 1 (DGAT1) and myogenic factor 5 (MYF5) genes play an important role in the physiology of lipid and muscle metabolism and are therefore considered as candidate genes for meat production traits in farm animals. The objectives of this study were to investigate single nucleotide polymorphisms (SNPs) in IGF1, TG, DGAT1 and MYF5 genes and to evaluate whether these polymorphisms affected meat colour, tenderness and cooking loss in Holstein cattle. Initially, the SNPs were detected by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method. Meat samples (N= 50) derived from M. longissimus thoracis et lumborum (LTL) were used in the current study. Significant differences in variations of meat colour parameters were observed at 24 hours post-mortem. IGF1 was associated with colour parameters of a* and chroma values. In addition, effects of TG were statistically significant on L* and a* values, while, effects of MYF5 were significant on a* value. There was no association of the tested SNPs with meat pH, tenderness and cooking loss. The results presented here may give the valuable information for improving meat colour in cattle.

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Synteny mapping of the bovine IGHG2, CRC and IGF1 genes

Cited by 21 publications

References 17 publications

Gene expression profile of intramuscular muscle in Nellore cattle with extreme values of fatty acid

Gene expression profile of intramuscular muscle in Nellore cattle with extreme values of fatty acid

IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows

Relationship of the bovine IGF1, TG, DGAT1 and MYF5 genes to meat colour, tenderness and cooking loss

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