Synteny and Chromosome Evolution in the Lepidoptera: Evidence From Mapping in <i>Heliconius melpomene</i>

Pringle, Elizabeth G.; Baxter, Simon W.; Webster, Claire L.; Papanicolaou, Alexie; Lee, Siu Fai; Jiggins, Chris D.

doi:10.1534/genetics.107.073122

Cited by 103 publications

(134 citation statements)

References 38 publications

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“…Overall conservation of synteny in Lepidoptera has been reported in several studies (16)(17)(18)(19)(20) suggesting that, over the 100 My separating the Bombyx and butterfly lineages, some degree of gene synteny has thus been maintained. However, a more detailed study was warranted to allow more general conclusions.…”

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confidence: 69%

“…In a study of 72 orthologous loci between B. mori and Heliconius melpomene, a very high degree of conserved synteny was observed, with 21 linkage groups (LGs) of the butterfly mapped with one to seven genes in common with the silkworm. However, only one chromosomal inversion was noted, and it is probable that the density of markers per LG did not allow the detection of more rearrangements (17). A study on Bicyclus anynana with 462 markers documented a high degree of macrosyntenic relationships between the 28 chromosomes of B. mori and the 23 LGs of B. anynana.…”

Section: Discussionmentioning

confidence: 99%

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Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements

d’Alençon

Sezutsu

Legeai³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

152

137

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The recent assembly of the silkworm Bombyx mori genome with 432 Mb on 28 holocentric chromosomes has become a reference in the genomic analysis of the very diverse Order of Lepidoptera. We sequenced BACs from two major pests, the noctuid moths Helicoverpa armigera and Spodoptera frugiperda, corresponding to 15 regions distributed on 11 B. mori chromosomes, each BAC/region being anchored by known orthologous gene(s) to analyze syntenic relationships and genome rearrangements among the three species. Nearly 300 genes and numerous transposable elements were identified, with long interspersed nuclear elements and terminal inverted repeats the most abundant transposable element classes. There was a high degree of synteny conservation between B. mori and the two noctuid species. Conserved syntenic blocks of identified genes were very small, however, approximately 1.3 genes per block between B. mori and the two noctuid species and 2.0 genes per block between S. frugiperda and H. armigera. This corresponds to approximately two chromosome breaks per Mb DNA per My. This is a much higher evolution rate than among species of the Drosophila genus and may be related to the holocentric nature of the lepidopteran genomes. We report a large cluster of eight members of the aminopeptidase N gene family that we estimate to have been present since the Jurassic. In contrast, several clusters of cytochrome P450 genes showed multiple lineagespecific duplication events, in particular in the lepidopteran CYP9A subfamily. Our study highlights the value of the silkworm genome as a reference in lepidopteran comparative genomics.comparative genomics | silkworm | Noctuidae | transposable elements | gene clusters

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mentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements

d’Alençon

Sezutsu

Legeai³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

152

137

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“…2005; Pringle et al. 2007; Davey et al. 2016), and we could find no evidence to the contrary in any of our crosses (Fig.…”

Section: Resultsmentioning

confidence: 99%

No evidence for maintenance of a sympatricHeliconiusspecies barrier by chromosomal inversions

et al. 2017

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Mechanisms that suppress recombination are known to help maintain species barriers by preventing the breakup of coadapted gene combinations. The sympatric butterfly species Heliconius melpomene and Heliconius cydno are separated by many strong barriers, but the species still hybridize infrequently in the wild, and around 40% of the genome is influenced by introgression. We tested the hypothesis that genetic barriers between the species are maintained by inversions or other mechanisms that reduce between‐species recombination rate. We constructed fine‐scale recombination maps for Panamanian populations of both species and their hybrids to directly measure recombination rate within and between species, and generated long sequence reads to detect inversions. We find no evidence for a systematic reduction in recombination rates in F1 hybrids, and also no evidence for inversions longer than 50 kb that might be involved in generating or maintaining species barriers. This suggests that mechanisms leading to global or local reduction in recombination do not play a significant role in the maintenance of species barriers between H. melpomene and H. cydno.

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“…The ECB diverged from Bombyx mori (the silk moth)~100 Mya (Pringle et al, 2007); however, the species pair shows a high degree of conservation in gene order like many other Lepidoptera (Pringle et al, 2007;d'Alencon et al, 2010;Kroemer et al, 2011). Therefore, we relied on the B. mori genome to identify evenly spaced sex-linked mapping loci for the ECB, whose genome is incomplete.…”

Section: Recombination Suppressionmentioning

confidence: 99%

A recombination suppressor contributes to ecological speciation in OSTRINIA moths

Wadsworth

Dopman

2015

Heredity

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Despite unparalleled access to species' genomes in our post-genomic age, we often lack adequate biological explanations for a major hallmark of the speciation process-genetic divergence. In the presence of gene flow, chromosomal rearrangements such as inversions are thought to promote divergence and facilitate speciation by suppressing recombination. Using a combination of genetic crosses, phenotyping of a trait underlying ecological isolation, and population genetic analysis of wild populations, we set out to determine whether evidence supports a role for recombination suppressors during speciation between the Z and E strains of European corn borer moth (Ostrinia nubilalis). Our results are consistent with the presence of an inversion that has contributed to accumulation of ecologically adaptive alleles and genetic differentiation across roughly 20% of the Ostrinia sex chromosome (~4 Mb). Patterns in Ostrinia suggest that chromosomal divergence may involve two separate phases-one driving its transient origin through local adaptation and one determining its stable persistence through differential introgression. As the evolutionary rate of rearrangements in lepidopteran genomes appears to be one of the fastest among eukaryotes, structural mutations may have had a disproportionate role during adaptive divergence and speciation in Ostrinia and in other moths and butterflies.

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Synteny and Chromosome Evolution in the Lepidoptera: Evidence From Mapping in Heliconius melpomene

Cited by 103 publications

References 38 publications

Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements

Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements

No evidence for maintenance of a sympatricHeliconiusspecies barrier by chromosomal inversions

A recombination suppressor contributes to ecological speciation in OSTRINIA moths

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