Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury

Lu, Quan; Zhang, Yong; Botchway, Benson O. A.; Huang, Min; Liu, Xuehong

doi:10.1007/s12035-023-03494-6

Cited by 3 publications

(1 citation statement)

References 101 publications

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“…Enhanced regeneration of corticospinal tracts (CST) passing through a spinal cord lesion, accelerated regrowth of monoaminergic axons across a transection gap, and increased compensatory sprouting of uninjured CST in SNPH −/− mice were found in three mouse models, respectively. Axonal regeneration involves reconstruction of the cytoskeleton, synthesis, transport of raw materials, and adequate energy supply to form functional growth cones ( Lu Q. et al, 2023 ). It is reasonable to believe that an in-depth study on mitochondrial transport will be an essential foundation for future SCI repair.…”

Section: Evidence For the Involvement Of Mitochondrial Transport In A...mentioning

confidence: 99%

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Lu,

Feng,

Liu

et al. 2023

Front. Neurosci.

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Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.

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Section: Evidence For the Involvement Of Mitochondrial Transport In A...mentioning

confidence: 99%

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Lu,

Feng,

Liu

et al. 2023

Front. Neurosci.

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Investigating the role of SARM1 in central nervous system

Wang,

Shi,

Tian

et al. 2024

Ibrain

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Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1), a key intracellular molecule that plays numerous important biological functions in the nervous system, has attracted much attention. Recent studies have shown that SARM1 plays a key role in nerve injury, degeneration, and neurodegenerative diseases. Therefore, understanding the role of SARM1 in the central nervous system (CNS) will enhance our knowledge of the pathogenesis of CNS diseases and aid in the development of new therapeutic strategies. This review will explore the biological functions of SARM1 in the nervous system and its potential roles in nerve injury and disease, thus providing new directions for future research and treatment.

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Metabolic reprogramming: a new option for the treatment of spinal cord injury

Chen,

et al. 2024

Neural Regeneration Research

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Spinal cord injuries impose a notably economic burden on society, mainly because of the severe after effects they cause. Despite the ongoing development of various therapies for spinal cord injuries, their effectiveness remains unsatisfactory. However, a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic reprogramming. In this review, we explore the metabolic changes that occur during spinal cord injuries, their consequences, and the therapeutic tools available for metabolic reprogramming. Normal spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic coupling. However, spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism, lipid metabolism, and mitochondrial dysfunction. These metabolic disturbances lead to corresponding pathological changes, including the failure of axonal regeneration, the accumulation of scarring, and the activation of microglia. To rescue spinal cord injury at the metabolic level, potential metabolic reprogramming approaches have emerged, including replenishing metabolic substrates, reconstituting metabolic couplings, and targeting mitochondrial therapies to alter cell fate. The available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord injury. To further advance the metabolic treatment of the spinal cord injury, future efforts should focus on a deeper understanding of neurometabolism, the development of more advanced metabolomics technologies, and the design of highly effective metabolic interventions.

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Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury

Cited by 3 publications

References 101 publications

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Investigating the role of SARM1 in central nervous system

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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