Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis

Krenn, Veit; Morawietz, Lars; Burmester, Gerd R; Kinne, Raimund W.; Müeller-Ladner, Ulf; Müller, Brigitte; Häupl, Thomas

doi:10.1111/j.1365-2559.2006.02508.x

Cited by 584 publications

(526 citation statements)

References 17 publications

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“…The subchondral bone also undergoes remodeling during OA, and these changes were assessed by radiography and bone histomorphometric parameters 127 of BV/TV and Tb.Th (which typically increase in OA) and Tb.N and Tb.Sp (which typically decrease in OA). Synovitis, which is atypical in OA, were characterized using the Krenn scoring scale 128,129 .…”

Section: Animal Models Of Oamentioning

confidence: 99%

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Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Lin

Seeto

Bartoszko

et al. 2009

Nat Med

293

340

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Osteoarthritis is associated with the irreversible degeneration of articular cartilage. Notably, in this condition, articular cartilage chondrocytes undergo phenotypic and gene expression changes that are reminiscent of their end-stage differentiation in the growth plate during skeletal development. Hedgehog (Hh) signaling regulates normal chondrocyte growth and differentiation; however, the role of Hh signaling in chondrocytes in osteoarthritis is unknown. Here I examined human osteoarthritic samples and mice in which osteoarthritis was surgically induced and find that Hh signaling is activated in osteoarthritis. Using several genetically modified mice, I found that higher levels of Hh signaling in chondrocytes cause a more severe osteoarthritic phenotype. Furthermore, Ishow in mice and in human cartilage explants that pharmacological or genetic inhibition of Hh signaling reduces the severity of osteoarthritis and that runtrelated transcription factor-2 (Runx2) potentially mediates this process by regulating a disintegrin and metalloproteinase with thrombospondin type 1 motif-5 (Adamts5) expression. Together, these findings raise the possibility that Hh blockade can be used as a therapeutic approach to inhibit articular cartilage degeneration.iii ACKNOWLEDGEMENTS

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Section: Animal Models Of Oamentioning

confidence: 99%

“…For each sample, a minimum of 12 levels were graded using the ICRS method of scoring 125 , a synovitis scoring scale 128 , and a semi-quantitative scoring system.…”

Section: Icrs Scoring Synovitis Scoring and Immunostainingmentioning

confidence: 99%

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Lin

Seeto

Bartoszko

et al. 2009

Nat Med

293

340

View full text Add to dashboard Cite

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“…The histopathologic synovitis grading scale [20,21] we used does not predict biomechanical cartilage properties. Although this grading system is the only established score [45], it is intended primarily to differentiate between OA and rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation of the synovium was assessed using a validated histopathologic grading system [20,21] which includes an analysis of the following morphologic alterations: (1) hyperplasia/enlargement of synovial lining cell layer; (2) activation of resident cells/synovial stroma; and (3) inflammatory infiltration. Each histopathologic quality is graded from absent (0), slight (1), and moderate (2), to strong (3), with summaries ranging from 0 (no inflammation) to 9 (strong synovitis).…”

Section: Histologymentioning

confidence: 99%

Does Intraarticular Inflammation Predict Biomechanical Cartilage Properties?

Waldstein

Perino

Jawetz

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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“…However, no significant difference was observed in chondrocyte viability between low-energy and high-energy fractures (p = 0.68). Furthermore, the work of Krenn et al in humans was modified for use in the murine model to show that the inflammatory response differed between experimental and control limbs seven days after injury 26 . Low-energy fractures had synovitis present in the lateral (fractured) portion of the joint.…”

Section: Early Diagnosis Enables Early Treatment To Reduce Osteoarthrmentioning

confidence: 99%

Osteoarthritis: From Palliation to Prevention

Chu

Millis

Olson

2014

The Journal of Bone and Joint Surgery

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Osteoarthritis is a leading cause of disability. The traditional focus on late-stage osteoarthritis has not yielded effective disease-modifying treatments. Consequently, current clinical care focuses on palliation until joint replacement is indicated. A symposium format was used to examine emerging strategies that support the transformation of the clinical approach to osteoarthritis from palliation to prevention. Central to this discussion are concepts for diagnosis and treatment of pre-osteoarthritis, meaning joint conditions that increase the risk of accelerated development of osteoarthritis. The presentation of translational and clinical research on three common orthopaedic conditions-anterior cruciate ligament tear, intra-articular fracture, and hip dysplasia-were used to illustrate these ideas. New information regarding the use of novel quantitative magnetic resonance imaging (MRI) in the form of ultrashort echo time enhanced T2* (UTE-T2*) mapping to evaluate the potential for articular cartilage to heal subsurface damage in a mechanically sound environment was presented. These data indicate that improved diagnostics can both identify cartilage at risk and evaluate the effectiveness of early treatment strategies. With use of a new mouse model for intra-articular fracture, it was shown that inflammation correlated to fracture severity and that super-healer mice avoided early posttraumatic osteoarthritis in part through an enhanced ability to dampen inflammation. These findings suggest that there is a role for acute and sustained anti-inflammatory treatment in the prevention of osteoarthritis. For long-term treatment, contemporary gene-therapy approaches may offer an effective means for sustained intra-articular delivery of anti-inflammatory and other bioactive agents to restore joint homeostasis. To illustrate the potential of early treatment to prevent or delay the onset of disabling osteoarthritis, the positive clinical effects on articular cartilage and in long-term clinical follow-up after operative correction of structural abnormalities about the hip highlight the role for targeting mechanical factors in delaying the onset of osteoarthritis. Given that orthopaedic surgeons treat the full spectrum of joint problems, ranging from joint trauma to preosteoarthritic conditions and end-stage osteoarthritis, an awareness of the paradigm shift toward the prevention of osteoarthritis is critical to the promotion of improved clinical care and participation in clinical research involving new treatment strategies.

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Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis

Abstract: The proposed synovitis score is based on well-defined, reproducible histopathological criteria and may contribute to diagnosis in rheumatic and non-rheumatic joint diseases.

Cited by 584 publications

References 17 publications

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Does Intraarticular Inflammation Predict Biomechanical Cartilage Properties?

Osteoarthritis: From Palliation to Prevention

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