Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium

Wang, X; Chen, T; Liang, Weihao; Fan, Tianxiang; Zhu, Zhaohua; Cao, Peihua; Ruan, Guangfeng; Zhang, Y; Chen, S; Wang, Q; Li, S; Huang, Yao; Zeng, Muhui; Hunter, David J.; Li, J; Ding, Changhai

doi:10.1016/j.joca.2022.06.004

Cited by 10 publications

(3 citation statements)

References 44 publications

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“…Consequently, there is an urgent need for more comprehensive research into the pathogenesis of OA and the development of innovative therapeutic strategies. Synovitis, the in ammation of the synovial membrane, has been identi ed as a critical factor contributing to joint pain and restricted mobility in OA patients 4 . The in amed synovium is known to produce a variety of pro-in ammatory mediators, including prostaglandins, leukotrienes, reactive oxygen species, cytokines, chemokines, and adipokines, all of which play signi cant roles in the degradation of articular cartilage and the ampli cation of the in ammatory response 5 .…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Deciphering the Autophagic Machinery: Unveiling Novel Genes in Osteoarthritis Synovial Tissue through Bioinformatics Analysis

Jiao,

Li,

Yang

et al. 2024

Preprint

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Background Autophagy is a crucial cellular homeostatic mechanism that primarily influences osteoarthritis (OA) by modulating inflammation. Despite its recognized role in the broader context of OA, the specific effects of autophagy on OA-associated synovitis are not yet well understood. Objective This study aims to identify and validate potential autophagy-related genes (ARGs) involved in OA synovitis using bioinformatics analysis. Methods The synovial bulk RNA-seq dataset GSE55235 was acquired from the GEO database. Initially, this dataset was analyzed to evaluate autophagy levels between the OA synovial group and the healthy synovial group. Subsequently, differentially expressed genes (DEGs) and differentially expressed ARGs (DEARGs) were identified through differential analysis. Functional enrichment analysis was performed to investigate the possible biological functions and pathways of DEARGs. Additionally, the protein-protein interaction (PPI) network of DEARGs was constructed, and the hub genes were identified. Lastly, the Network Analyst platform was used to predict target miRNAs for the hub genes. Results Autophagy levels were significantly lower in the OA synovial group compared to the healthy synovial group. Thirteen DEARGs were identified, mainly enriched in mitophagy, the FoxO signaling pathway, and the PI3K-Akt signaling pathway. MYC, CDKN1A, and FOXO3 were recognized as key ARGs in OA synovitis. The accuracy of these genes was confirmed by analyzing two additional synovial bulk RNA-seq datasets. Moreover, three miRNAs targeting these hub genes were identified using the NetworkAnalyst platform. Conclusion This study identified and validated three hub ARGs in OA synovitis through bioinformatics analysis. These findings offer valuable insights for future research.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Deciphering the Autophagic Machinery: Unveiling Novel Genes in Osteoarthritis Synovial Tissue through Bioinformatics Analysis

Jiao,

Li,

Yang

et al. 2024

Preprint

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“…In this case, we believe that the symptoms in the patient's left knee joint may caused by xanthoma. The synovitis caused by xanthoma and the occupation within the joint led to the patient experiencing knee joint pain, limited functional activity, and an elevated level of in ammation 9,10 . Through arthroscopic surgery, after removing a signi cant portion of the xanthoma and synovial tissue, in ammatory factors were reduced within the knee joint, resulting in a signi cant improvement in the symptoms of the patient's left knee joint.…”

Section: Resultsmentioning

confidence: 99%

Xanthoma Combining Osteonecrosis in Knee Joint: A Case Report

Su,

Gong,

Chen

et al. 2024

Preprint

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Xanthoma typically occurs in the subcutaneous tissues, with rare cases of osseous xanthoma. However, the occurrence of knee joint osteonecrosis combined with xanthoma is even more uncommon. To the best of our knowledge, this is the first reported case. In this article, we describe a 50-year-old female patient who developed xanthoma on the basis of osteonecrosis of the knee joint. The primary clinical symptoms were knee joint pain and limited mobility. Despite conventional treatments for osteonecrosis, there was no significant improvement. Subsequently, she underwent arthroscopic excision of the knee joint xanthoma. Following the procedure, her VAS score decreased from 7 to 2, and knee joint mobility increased from 10-103° to 10-140°. Through our follow-up, the patient did not exhibit symptom recurrence. This case is valuable and provides a feasible therapeutic approach for future clinical applications.

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“…The components of synovial fluid are mainly derived from synovial tissue, which includes various inflammatory irritants that contribute to cartilage destruction ( Wang et al, 2015 ; Qi et al, 2020 ). In recent years, attention has begun to be paid to the importance of synovium in the etiology of OA, and some studies have even proposed synovitis as an independent risk factor for OA ( Felson et al, 2016 ; MacFarlane et al, 2019 ; Wang et al, 2022 ). And we found much higher levels of IL-37 in the synovial membrane than in the articular disc, cartilage and condyle ( Luo et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

Li,

Peng,

Yan

et al. 2023

Front. Pharmacol.

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Background: The temporomandibular joint is often afflicted by osteoarthritis (TMJOA), causing pain and dysfunction, which is particularly prevalent in the elderly population. IL-37 is effective in avoiding excessive inflammatory damage to the organism. This article investigates the role and mechanism of intracellular IL-37 in TMJOA.Methods: Enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, Western blotting, Senescence-associated β-galactosidase staining, immunofluorescence, and lentivirus were performed to elucidate the underlying mechanism.Results: The results confirmed that IL-37 in synovial cells decreased with aging. Inflammatory stimulus elevated intracellular IL-37 in synoviocytes, while lentiviral knockdown of IL-37 resulted in more inflammatory factor production. Dynamic changes of IL-37 were observed in the nucleus and supernatant. In addition, Caspease-1 inhibitor hindered intracellular IL-37 maturation, and Smad3 inhibitor caused the loss of nuclear translocation of mature IL-37. Transfection of synovial cells with IL-37-expressing lentivirus resulted in relief not only of synovitis but also of the cartilage damage and inflammation caused by synovitis.Conclusion: This study provides new insights into the intracellular anti-inflammatory mechanism of IL-37. It also confirms that IL-37 decreases with cellular senescence and that increasing intracellular IL-37 can effectively treat synovitis and synovitis-induced inflammatory damage to cartilage.

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Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium

Cited by 10 publications

References 44 publications

RETRACTED: Deciphering the Autophagic Machinery: Unveiling Novel Genes in Osteoarthritis Synovial Tissue through Bioinformatics Analysis

RETRACTED: Deciphering the Autophagic Machinery: Unveiling Novel Genes in Osteoarthritis Synovial Tissue through Bioinformatics Analysis

Xanthoma Combining Osteonecrosis in Knee Joint: A Case Report

IL-37 counteracts inflammatory injury in the temporomandibular joint via the intracellular pathway

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