Synovial Sarcoma of Tonsil and Tongue Base

Engelhardt, John F.; Leafstedt, Stuart W.

doi:10.1097/00007611-198302000-00025

Cited by 18 publications

(15 citation statements)

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“…Primary tonsillar HNSS has been previously documented only in three other patients [3][4][5]. In all of these patients the tumors were histologically biphasic, but only one showed areas of poor differentiation as in our case.…”

Section: Discussionsupporting

confidence: 60%

“…The most common site for HNSS is the hypopharynx, but other sites (masticator space, sinonasal cavity, pharynx, parapharyngeal space, tongue, and trachea) have also been described [1][2][3][4][5][8][9][10]. Primary tonsillar HNSS has been previously documented only in three other patients [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

“…This patient only underwent surgery. The second patient (age and tumor size not reported) received additional post-operative radio-and chemotherapy [4]. During the reported follow-up times of 38 months and 10 years, respectively, no local or systemic recurrence occured.…”

Section: Discussionmentioning

confidence: 99%

“…It may occur at any site in the body, however only 3-5% of SS arise in the head and neck region [1][2][3]. We describe the clinical, pathological, and molecular pathological findings in a biphasic, focal poorly differentiated SS in the left palatine tonsil (T-PDSS), a rare site of this tumor [3][4][5]. We also discuss the relevance of our findings with regard to prognostic and therapeutic considerations in SS, particularly in the head and neck region (HNSS).…”

Section: Introductionmentioning

confidence: 99%

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Molecular and Clinicopathological Findings in a Tonsillar Synovial Sarcoma. A Case Study and Review of the Literature

Vogel

Wehrmann

Eichhorn

et al. 2010

Head and Neck Pathol

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Synovial sarcoma (SS), 3-5% of which occurs in the head and neck region, has generally been regarded as high grade sarcoma. Recent analysis of clinical, morphological, and molecular characteristics of SS, however, identified low and high risk group of patients, resulting in important implications for the treatment of patients diagnosed with SS. We describe the case of a 31-year-old male who presented with biphasic SS with poorly differentiated areas (clinical stage IIA) in a palatine tonsil, an extremely rare site of SS. Molecular analyses revealed typical t(X;18) translocation of the SYT gene and a SYT/SSX1 fusion type. The tumor was surgically resected with free margins. Adjuvant radiotherapy or chemotherapy was not considered indicated. To date, the patient has remained free of tumor for 4 years after surgery. Literature review reveals that primary tonsillar HNSS has previously been documented only in three patients. In all of these patients the tumor was histologically biphasic; however only one published case and the case presented here showed areas of poor differentiation. We discuss the relevance of the presented findings with regard to prognostic and therapeutic considerations in SS in the head and neck region.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular and Clinicopathological Findings in a Tonsillar Synovial Sarcoma. A Case Study and Review of the Literature

Vogel

Wehrmann

Eichhorn

et al. 2010

Head and Neck Pathol

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“…In most cases it arises from the pharyngeal region rather than from other structures [5,[9][10][11][12][13][14][15][16][17][18][19].…”

mentioning

confidence: 99%

SYNOVIAL SARCOMA OF THE NECK IN A CHILD: A Multidisciplinary Approach

Farruggia¹,

D’Angelo²,

Cascio³

et al. 2008

Pediatric Hematology and Oncology

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Synovial sarcoma (SS) is the most common nonrhabdomyosarcomatous soft tissue sarcoma in childhood, but the head-neck site accounts for less than 5% of cases. The authors report a 10-year-old boy with SYT-SSX1 positive left parapharyngeal SS, resistant to front-line VAIA chemotherapy, who obtained a good partial response by salvage regimen (I(3)VE + CEV + I(3)VE) and local radiotherapy, so a complete surgical resection could be performed. The complete remission was subsequently consolidated by ablative high-dose chemotherapy, followed by autologous stem cell reinfusion. The child remains in complete remission at 36 months after completion of treatment.

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Synovial Sarcomas of the Tongue Base: The Seventh Reported Case

Holtz¹,

Magielski²

1985

Archives of Otolaryngology - Head and Neck Surgery

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Synovial Sarcoma of Tonsil and Tongue Base

Cited by 18 publications

References 0 publications

Molecular and Clinicopathological Findings in a Tonsillar Synovial Sarcoma. A Case Study and Review of the Literature

Molecular and Clinicopathological Findings in a Tonsillar Synovial Sarcoma. A Case Study and Review of the Literature

SYNOVIAL SARCOMA OF THE NECK IN A CHILD: A Multidisciplinary Approach

Synovial Sarcomas of the Tongue Base: The Seventh Reported Case

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