Synovial Sarcoma in Children: Surgical Lessons From A Single Institution and Review of The Literature

Andrassy, Richard J.; Okcu, M. Fatih; Despa, Simona; Raney, R. Beverly

doi:10.1016/s1072-7515(00)00806-1

Cited by 75 publications

(45 citation statements)

References 18 publications

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“…During the last several decades, much effort has been invested in determining prognostic factors affecting overall survival in patients with synovial sarcoma. Histologic subtype, tumor grade, anatomic location, age, gender, tumor size, and surgical margins have been reported to have prognostic implication for a patient's overall survival [1,2,6,9,12,16,17,[19][20][21][22][23][24]. In our study, histologic subtype, grade, anatomic location, size, age, and surgical margins did not predict overall survival.…”

Section: Discussioncontrasting

confidence: 45%

“…Primary tumor size [1,2,12,16,17,[20][21][22][23]27], tumor stage [20,23], gender [6,23,27], age [2,6,12,17,19,21,27], tumor grade [6,23], histologic subtype [2,17,19,20,23], tumor necrosis [23], mitotic activity [23], invasion of bone and neurovascular structures [1,16], and anatomic tumor location [6,9,17,19,23] all influence the natural history of primary synovial sarcomas. However, many of these findings have not been consistent so definitive conclusions based on them cannot be made.…”

Section: Introductionmentioning

confidence: 99%

“…We therefore (1) prospectively assessed the prognostic value of pretherapy FDG-PET SUV max in survival in patients with synovial sarcoma and (2) determined whether age, gender, histopathologic subtype, grade, margins at the time of resection, tumor size, anatomic location, and metastasis at presentation predicted survival.…”

Section: Introductionmentioning

confidence: 99%

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Risk Assessment Based on FDG-PET Imaging in Patients with Synovial Sarcoma

Lisle

Eary

O’Sullivan

et al. 2008

Clin Orthop Relat Res

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Synovial sarcoma generally is associated with poor prognosis. With recent advances in molecular biology, it has become apparent not all synovial sarcomas share the same tumor biology. 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) is useful for risk assessment in several types of sarcomas. We therefore assessed the clinical value of 18 F-FDG-PET-derived maximum standard uptake value (SUV max ) for predicting survival in patients with synovial sarcoma. 18 F-FDG-PET was performed in 44 patients with synovial sarcoma before therapy and resection. SUV max was calculated for each tumor and then evaluated for prognostic usefulness along with metastasis at presentation, tumor grade, histopathologic subtype, age, gender, postsurgical margins, anatomic location, and tumor size for overall survival and progression-free survival. SUV max ranged from 1.2 to 13.0 (median, 4.35). Pretherapy tumor SUV max predicted overall survival and progression-free survival. Patients presenting with a SUV max greater than 4.35 had a decreased diseasefree survival and were therefore at high risk for having local recurrences and metastatic disease.

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Section: Discussioncontrasting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

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Risk Assessment Based on FDG-PET Imaging in Patients with Synovial Sarcoma

Lisle

Eary

O’Sullivan

et al. 2008

Clin Orthop Relat Res

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“…Desmin often is positive in rhabdomyosarcoma [37,38] and it also is seen in AFH [20]. Synovial sarcoma is the most common nonrhabdomyosarcoma soft tissue malignancy seen in children, comprising 7% to 8% of all pediatric malignant soft tissue tumors [1]. Similar to AFHs, synovial sarcomas primarily occur in the extremities [22,42] and are deepseated [22].…”

Section: Discussion and Treatmentmentioning

confidence: 99%

Orthopaedic Case of the Month: A 14-Year-Old Boy With a Medial Thigh Soft Tissue Mass

Ibrahim

Mascarenhas

Tovar

et al. 2013

Clinical Orthopaedics &Amp; Related Research

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“…Joint cavity involvement has been reported to occur in less than 5% of patients. [4,5] In the extremities, the single most common site for synovial sarcoma is the knee joint, followed by the ankle/foot, elbow, and upper arm/shoulder joint. Joint cavity involvement is rare, and the joint most commonly affected is the knee.…”

Section: Discussionmentioning

confidence: 99%