Synovial sarcoma: defining features and diagnostic evolution

Thway, Khin; Fisher, Cyril

doi:10.1016/j.anndiagpath.2014.09.002

Cited by 243 publications

(308 citation statements)

References 176 publications

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“…Nuclear expression of myogenin or MYOD1 is a consistent and diagnostic feature [17]. Cytokeratin expression may be focal in the monophasic spindle cell synovial sarcoma and strong nuclear reactivity to TLE1 is seen [18].…”

Section: Differential Diagnosismentioning

confidence: 94%

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity

Rawal

Anderson

Dodson

2016

Head and Neck Pathol

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Section: Differential Diagnosismentioning

confidence: 94%

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity

Rawal

Anderson

Dodson

2016

Head and Neck Pathol

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“…The synovial sarcoma constitutes ~10% of soft tissue sarcomas. Treatment for this type of sarcoma consists of radical or wide excision of the tumor with adjuvant therapy (chemotherapy and/or radiation therapy) (28). A previous report on fibrosarcoma revealed unsatisfactory results with chemotherapy, while the complete removal of the tumor resulted in survival without local reoccurrence (29).…”

Section: Discussionmentioning

confidence: 99%

Chest wall tumors: Diagnosis, treatment and reconstruction

Lin

Huang

et al. 2015

Experimental and Therapeutic Medicine

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The aim of the present study was to determine a suitable procedure for the treatment of chest wall neoplasms with less potential risk and an increased rate of survival. Fifty patients with suspected chest wall malignancies were analyzed using various preliminary investigation tools. Whole-chest scanning was performed in all the patients. The patients were subsequently subjected to biopsies for further confirmation of the neoplasm. All such patients were then treated with a surgical approach and radiation therapy, with a follow-up period lasting up to six years. The majority of the patients showed improved survival rates relative to conventional therapies. The survival rates of patients suffering from osteosarcoma (78%) were higher those of patients with rhabdomyosarcoma (73%) and malignant small round cell tumors (64%). The survival and the mortality rates of the patients with synovial sarcoma and fibrosarcoma were the same. This study, which was conducted on a small group of patients, has provided guidance for further studies on tumors of the chest wall, which may, in turn, increase the longevity of affected patients.

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“…Synovial sarcoma typically will have a low-grade histological appearance, cellular pleomorphism and minimal atypical cytological features. The presence of the t(x;18)(p11;q11) chromosomal translocation is a specific finding found only in synovial sarcoma, but there have been cases where this translocation has been absent 3. While MDM2 overexpression is observed in all intimal sarcomas, it is not enough to distinguish it from undifferentiated sarcomas or angiosarcomas.…”

Section: Differential Diagnosismentioning

confidence: 99%

Intimal (spindle cell) sarcoma of the left atrium presenting with abnormal neurological examination

Saith¹,

Duzenli

Zavaro

et al. 2015

BMJ Case Reports

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A 43-year-old man with an unremarkable medical history presented to our hospital with 2 weeks of headaches, ataxia and confusion. CT of the head revealed a large haemorrhagic cystic lesion. A subsequent chest CT revealed a large left atrial mass. The mass was subsequently biopsied with positive immunohistochemistry staining for MDM2, FLI1 and vimentin. Real-time PCR revealed MDM2 amplification, confirming the diagnosis of intimal sarcoma. The patient underwent surgical resection and reconstruction of the atrium with subsequent discharge to short-term rehabilitation, but his symptoms continued to progress. A repeat CT of the head revealed a new cerebellar mass. He underwent a second resection, but continued to experience worsening symptoms. He was diagnosed with stage IV intimal sarcoma and referred to hospice. The patient died 5 months after initial presentation. Autopsy was performed and revealed the cause of death as pneumonia. There was no involvement of the pulmonic or aortic vessels.

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Synovial sarcoma: defining features and diagnostic evolution

Cited by 243 publications

References 176 publications

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed in the Oral Cavity

Chest wall tumors: Diagnosis, treatment and reconstruction

Intimal (spindle cell) sarcoma of the left atrium presenting with abnormal neurological examination

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