Synovial sarcoma

Palmerini, Emanuela; Staals, Eric L.; Alberghini, Marco; Zanella, Licciana; Ferrari, Cristina; Benassi, Maria Serena; Picci, Piero; Mercuri, Mario; Bacci, Gaetano; Ferrari, S.

doi:10.1002/cncr.24370

Cited by 142 publications

(77 citation statements)

References 30 publications

(100 reference statements)

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“…This rate seems to be lower than in other studies reported before. It has to be mentioned that in these trials median follow-up was longer (from 5.5 up to 13.2 years) as compared to our study (23 months) [9,10,16,17,24]. …”

Section: Discussionmentioning

confidence: 74%

“…Other studies reported a higher DFS rate after 5 years, i.e. between 58 and 62% mainly due to the inclusion of more patients, as well as a longer median follow-up [9,17,24,29]. …”

Section: Discussionmentioning

confidence: 99%

“…All patients received surgery, radiation therapy and, if indicated, chemotherapy. The 5-year OS rate for initially localized and metastatic SS was 76 and 10%, respectively [24]. …”

Section: Introductionmentioning

confidence: 99%

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Initially Localized Synovial Sarcoma in Adults: A Retrospective Single-Center Analysis of 26 Patients Registered at the Department of Oncology, University of Vienna between 2004 and 2013

et al. 2014

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Background: Synovial sarcoma is a rare subgroup of all soft-tissue sarcomas. The aim of this retrospective single-center analysis was to investigate the outcome of patients with initially localized disease. Patients and Methods: Twenty-six patients were enrolled in this retrospective single-center analysis. Baseline characteristics, treatment and outcome were evaluated. Results: In 13 patients (50%), the tumor was located in the lower extremity and in 4 patients (15%) in the upper extremity. Surgical resection was done in all but 2 patients (92%). Re-resection was done in 7 patients (27%). Fourteen patients (54%) received adjuvant chemotherapy. After a median follow-up of 23.3 months (range: 2.6-150.3), median disease-free survival was not reached at the time of analysis. Eight patients (31%) relapsed after initial therapy. Surgery was done in 2 patients, amputation in 1 patient, palliative chemotherapy was administered in 3 and radiation therapy in 2 patients. Median overall survival (OS) for all patients was not reached at the time of analysis. The estimated 5-year OS rate was 62%. Conclusion: Patients with initially localized synovial sarcoma who were included in this retrospective single-center analysis have an estimated 5-year OS rate of 62%.

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Section: Discussionmentioning

confidence: 74%

“…Other studies reported a higher DFS rate after 5 years, i.e. between 58 and 62% mainly due to the inclusion of more patients, as well as a longer median follow-up [9,17,24,29]. …”

Section: Discussionmentioning

confidence: 99%

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Initially Localized Synovial Sarcoma in Adults: A Retrospective Single-Center Analysis of 26 Patients Registered at the Department of Oncology, University of Vienna between 2004 and 2013

et al. 2014

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“…Location is mainly 71% in the lower and 16% in the upper extremities (Palmerini et al, 2009). Local symptoms in specific sites can also be observed.…”

Section: Clinical Featuresmentioning

confidence: 97%

Synovial Sarcoma Metastasized to the Brain

Sakellaridis¹,

Sakellaridi²

2014

Brain Metastases From Primary Tumors

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“…It usually affects the extremities of young patients around the age of 35 years [1, 3]. Although called synovial sarcoma, it is rarely intra-articular [4].…”

Section: Introductionmentioning

confidence: 99%

Case report: synovial sarcoma of the axilla with brachial plexus involvement

et al. 2018

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BackgroundSynovial sarcoma is a rare soft tissue sarcoma which most commonly affects the extremities of young adults. Axilla involvement by this sarcoma is very rare especially with involvement of the brachial plexus. This combination adds to the challenge in approaching such tumors which might significantly affect survival and function.Case presentationHerein, we present a 48-year-old female patient who presented with an isolated painless lump in her right axilla. Initially, her workup, looking for possible breast cancer, included fine-needle aspiration (FNA) which did not provide the diagnosis. Core-needle biopsy, performed later, revealed monophasic synovial sarcoma. Her workup studies revealed no metastasis. Then, through extensile deltopectoral approach, the tumor was dissected out from within the brachial plexus. Ulnar nerve was sacrificed in order not to compromise the surgical margins which were confirmed tumor free by final pathology. The patient did not receive chemotherapy or radiation upon consultations with medical and radiation oncology teams. Her follow-up revealed no tumor recurrence with no restriction of her right shoulder motion.ConclusionOur case report represents a very rare occurrence of synovial sarcoma in the axilla with involvement of the brachial plexus. When clinical and radiological findings are suggestive of soft tissue sarcoma of the axilla, we recommend getting core-needle biopsy rather than fine-needle aspiration for earlier diagnosis. Early referral and multidisciplinary approach may contribute to better management.

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Synovial sarcoma

Cited by 142 publications

References 30 publications

Initially Localized Synovial Sarcoma in Adults: A Retrospective Single-Center Analysis of 26 Patients Registered at the Department of Oncology, University of Vienna between 2004 and 2013

Initially Localized Synovial Sarcoma in Adults: A Retrospective Single-Center Analysis of 26 Patients Registered at the Department of Oncology, University of Vienna between 2004 and 2013

Synovial Sarcoma Metastasized to the Brain

Case report: synovial sarcoma of the axilla with brachial plexus involvement

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