Synovial Mesenchymal Stem Cells Derived From the Cotyloid Fossa Synovium Have Higher Self-renewal and Differentiation Potential Than Those From the Paralabral Synovium in the Hip Joint

Murata, Yozo; Uchida, Soshi; Utsunomiya, Hidetsuna; Hatakeyama, Akihisa; Nakashima, Hirotaka; Chang, Angela; Sekiya, Ichiro; Sakai, Akinori

doi:10.1177/0363546518794664

Cited by 23 publications

(46 citation statements)

References 39 publications

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“…Murata et al [52] selected two parts for research: the paralabral synovium and the cotyloid fossa synovium, both of which come from the hip joint of femoroacetabular impingement syndrome patients. The anatomical location of the cotyloid fossa is defined in the lower part of the acetabulum, surrounded by the surface of the acetabular horseshoe-shaped crescent [53].…”

Section: Different Cell Subpopulations Of Sm-mscsmentioning

confidence: 99%

Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases

Gao

et al. 2020

Stem Cell Res Ther

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Mesenchymal stem cells (MSCs) can be isolated from not only bone marrow, but also various adult mesenchymal tissues such as periosteum, skeletal muscle, and adipose tissue. MSCs from different tissue sources have different molecular phenotypes and differentiation potential. Synovial membrane (SM) is an important and highly specific component of synovial joints. Previous studies have suggested that the synovium is a structure with a few cell layers thick and consists mainly of fibroblast-like synoviocytes (FLS), which forms a layer that lining the synovial membrane on the joint cavity and synovial fluid through cell-cell contact. In recent years, studies have found that there are also mesenchymal stem cells in the synovium, and as an important part of the mesenchymal stem cell family, it has strong capabilities of cartilage forming and tissue repairing. This article reviews the sources, surface markers, subtypes, influencing factors, and applications in inflammatory joints of synovial membrane mesenchymal stem cells (SM-MSCs) in recent years, aiming to clarify the research status and existing problems of SM-MSCs.

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Section: Different Cell Subpopulations Of Sm-mscsmentioning

confidence: 99%

Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases

Gao

et al. 2020

Stem Cell Res Ther

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“…One of the other aspects of the definition of MSCs offered by the ISCT is the differentiation potential of the cells into osteocytes, adipocytes, and chondrocytes in vitro. Synovium-derived MSCs have been shown to differentiate into these three cells [6, 49, 50]. Although Alt et al [46] found that fibroblasts exhibited no differentiation potential, other studies have shown that fibroblasts do possess the potential to differentiate into osteocytes, adipocytes, and chondrocytes [45, 47, 51].…”

Section: Introductionmentioning

confidence: 99%

Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells

Tang

Song

et al. 2019

Stem Cell Res Ther

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Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has long been a topic of debate. The terms “type B synoviocytes,” “fibroblast-like synoviocytes (FLS),” “synovium-derived mesenchymal stem cells (MSCs),” and “synovial fibroblasts (SF)” appeared in different articles related to human synovial-derived cells in various disease models, yet they seemed to be describing the same cell type. However, to date, there is no clear standard to distinguish these terms; thus, the hypothesis that they represent the same cell type is currently inconclusive. Therefore, this review aims to clarify the similarities and differences between these terms and to diffuse the chaotic nomenclature of synovial-derived cells.

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“…Researchers have conducted investigations of PBSCs in cartilage repair and regeneration because of the advantages of PBSCs and limitations of chondrogenic progenitor cells from other sources, such as bone marrow (Bain, 2003), synovial membranes (Murata et al, 2018), and adipose tissue (Kuroda et al, 2015). Increasing evidence has shown that PB-MSCs have a similar potential for proliferation and trilineage differentiation as BM-MSCs and might be a promising source of seed cells for cartilage repair (Wang et al, 2016b) since Fernández et al (Fernandez et al, 1997) reported the presence of stromal cells in hG-CSFmobilized PB from patients with breast cancer for the first time in 1997.…”

Section: Discussionmentioning

confidence: 99%

The Use of Peripheral Blood-Derived Stem Cells for Cartilage Repair and Regeneration In Vivo: A Review

et al. 2020

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Background: Peripheral blood (PB) is a potential source of chondrogenic progenitor cells that can be used for cartilage repair and regeneration. However, the cell types, isolation and implantation methods, seeding dosage, ultimate therapeutic effect, and in vivo safety remain unclear. Methods: PubMed, Embase, and the Web of Science databases were systematically searched for relevant reports published from January 1990 to December 2019. Original articles that used PB as a source of stem cells to repair cartilage in vivo were selected for analysis. Results: A total of 18 studies were included. Eight human studies used autologous nonculture-expanded PB-derived stem cells (PBSCs) as seed cells with the blood cell separation isolation method, and 10 animal studies used autologous, allogenic or xenogeneic culture-expanded PB-derived mesenchymal stem cells (PB-MSCs), or nonculture-expanded PBSCs as seed cells. Four human and three animal studies surgically implanted cells, while the remaining studies implanted cells by single or repeated intra-articular injections. 121 of 130 patients (in 8 human clinical studies), and 230 of 278 animals (in 6 veterinary clinical studies) using PBSCs for cartilage repair achieved significant clinical improvement. All reviewed articles indicated that using PB as a source of seed cells enhances cartilage repair in vivo without serious adverse events. Conclusion: Autologous nonculture-expanded PBSCs are currently the most commonly used cells among all stem cell types derived from PB. Allogeneic, autologous, and xenogeneic PB-MSCs are more widely used in animal studies and are potential seed cell types for future applications. Improving the mobilization and purification technology, and shortening the culture cycle of culture-expanded PB-MSCs will obviously promote the researchers' interest. The use of PBSCs for cartilage repair and regeneration in vivo are safe. PBSCs considerably warrant further investigations due to their superiority and safety in clinical settings and positive effects despite limited evidence in humans.

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Synovial Mesenchymal Stem Cells Derived From the Cotyloid Fossa Synovium Have Higher Self-renewal and Differentiation Potential Than Those From the Paralabral Synovium in the Hip Joint

Abstract: Synovial cells from the cotyloid fossa synovium of patients with femoroacetabular impingement syndrome are more robust in vitro, suggesting that MSCs from this source may be strongly considered for stem cell therapy.

Cited by 23 publications

References 39 publications

Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases

Synovial membrane mesenchymal stem cells: past life, current situation, and application in bone and joint diseases

Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells

The Use of Peripheral Blood-Derived Stem Cells for Cartilage Repair and Regeneration In Vivo: A Review

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