Synovial fluid proteomics and serum metabolomics reveal molecular and metabolic changes in osteoarthritis
Vishal Chandra,
Tashfeen Ashraf,
Pramod Yadav
et al.
Abstract:Background: Osteoarthritis (OA) is a common joint disorder with a complex and multifactorial pathogenesis. Proteomics analysis using two-dimensional gel electrophoresis (2DE) and mass spectrometry (MS) enables high-throughput identification of differentially expressed proteins related to OA. However, the etiology, pathophysiology, and early diagnostic markers of OA are still poorly understood. Methods: Synovial fluid protein biomarkers were compared between OA patients and healthy controls. It was fractionate… Show more
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