2018
DOI: 10.1021/acs.jproteome.8b00190
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Synovial Fluid Metabolites Differentiate between Septic and Nonseptic Joint Pathologies

Abstract: Osteoarthritis (OA), osteochondrosis (OC), and synovial sepsis in horses cause loss of function and pain. Reliable biomarkers are required to achieve accurate and rapid diagnosis, with synovial fluid (SF) holding a unique source of biochemical information. Nuclear magnetic resonance (NMR) spectroscopy allows global metabolite analysis of a small volume of SF, with minimal sample preprocessing using a noninvasive and nondestructive method. Equine SF metabolic profiles from both nonseptic joints (OA and OC) and … Show more

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Cited by 32 publications
(55 citation statements)
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“…Additional MS based metabolomics analysis of the culture media within this study may be beneficial as NMR and MS are complementary techniques and would therefore expand the number of identified/quantified metabolites, additionally identifying potential lipid and carbohydrate profiles of interest 9,38,43,102 . In order to confirm the differentially abundant proteins within this study, validation using an orthologous technique e.g.…”
Section: Further Workmentioning
confidence: 99%
See 3 more Smart Citations
“…Additional MS based metabolomics analysis of the culture media within this study may be beneficial as NMR and MS are complementary techniques and would therefore expand the number of identified/quantified metabolites, additionally identifying potential lipid and carbohydrate profiles of interest 9,38,43,102 . In order to confirm the differentially abundant proteins within this study, validation using an orthologous technique e.g.…”
Section: Further Workmentioning
confidence: 99%
“…However, the underlying pathogenesis of OA is yet to be fully elucidated with no disease-modifying treatments currently available 7,8 . Whilst a number of putative biomarkers have been identified for OA diagnosis in the horse, none are currently used within clinical practice 9 . Presently, equine OA is predominantly diagnosed through diagnostic imaging and clinical examination.…”
Section: Introductionmentioning
confidence: 99%
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“…It provides multi‐dimensional information on biochemical responses of complex systems to a range of intrinsic and environmental stimuli under specific circumstances , with the ultimate aim of serving as unique ‘fingerprints’ or disease biomarkers in named pathological states. Compared with other biochemical techniques, metabolomics requires minimal pretreatment and processing and has been used successfully in the rapid assessment of numerous systemic disease states in human and veterinary medicine . Metabolites within synovial fluid (SF) accurately represent activity of the surrounding synovial tissues, bones and cartilage and recent equine studies report successful differentiation of osteoarthritis , osteochondrosis and joint sepsis .…”
Section: Introductionmentioning
confidence: 99%