Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis

Zizzo, Gaetano; Santis, Maria De; Bosello, Silvia Laura; Fedele, Anna Laura; Peluso, Giusy; Gremese, Elisa; Tolusso, Barbara; Ferraccioli, Gianfranco

doi:10.1016/j.clim.2010.10.002

Cited by 57 publications

(55 citation statements)

References 48 publications

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“…Conversely rising levels of circulating Th17-cells and IL-17 were observed in patients with an inadequate response to anti-TNF-α therapy [35]. However, these finding were not observed in our study cohort since all the patients enrolled showed a good clinical response during ADA treatment.…”

Section: Discussioncontrasting

confidence: 53%

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A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab

Chimenti¹,

Morello²

2015

J Arthritis

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Section: Discussioncontrasting

confidence: 53%

“…TNF-α levels didn't discriminate between the two diseases, because of its common role in the pathogenesis of RA and PsA. These results highlight how the IL-23/IL-17 axis could be considered a major pro-inflammatory pathway, both systemic and local, in chronic inflammatory diseases as RA and PsA [35]. Furthermore, the indirect A.…”

Section: Discussionmentioning

confidence: 94%

A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab

Chimenti¹,

Morello²

2015

J Arthritis

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“…Hence, these data suggest that IL-17 and IL-17-driving cytokines enhance the acute-phase response, as well as stimulate anti-inflammatory cytokine IL-37 expression to downregulate excessive inflammation during the pathogenic process of RA. Furthermore, our findings found that there was no association between IL-37 and RF/anti-CCP, indicating the preponderant role of T cells in the pathogenesis of RA, because RF and anti-CCP Ab production were mainly derived from plasma cells and B lymphocytes (21).…”

Section: Discussionmentioning

confidence: 63%

IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation

Ye¹,

Jiang²,

Deng

et al. 2015

The Journal of Immunology

136

127

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IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associated with autoimmune diseases. This study was undertaken to evaluate whether IL-37 has antiarthritic effects in patients with rheumatoid arthritis (RA) and in mice with collagen-induced arthritis (CIA). In this study, we analyzed the expression of IL-37 in PBMCs, serum, and lymphocytes from RA patients as well as CD4+ T cells polarized under Th1/Th2/Th17 conditions. The role of IL-37 was assessed by investigating the effects of recombinant human (rh)IL-37 and an adenovirus encoding human IL-37 (Ad–IL-37) on Th17 cells and Th17-related cytokines in RA patients and CIA mice. We found that active RA patients showed higher IL-37 levels compared with patients with inactive RA and healthy controls. Upregulated IL-37 expression also was found in CD3+ T cells and CD4+ T cells from RA patients and in Th1/Th17-differentiation conditions. rhIL-37 markedly decreased IL-17 expression and Th17 cell frequency in PBMCs and CD4+ T cells from RA patients. Furthermore, IL-37 exerted a more suppressive effect on Th17 cell proliferation, whereas it had little or no effect on Th17 cell differentiation. IL-17 and IL-17–driving cytokine production were significantly reduced in synovium and joint cells from CIA mice receiving injections of Ad–IL-37. Our findings indicate that IL-37 plays a potent immunosuppressive role in the pathogenesis of human RA and CIA models via the downregulation of IL-17 and IL-17–triggering cytokine production and the curbing of Th17 cell proliferation.

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“…A detailed work by Steiner and coworkers (55) showed that although important in the generation of synovitis, the number of cytokineexpressing cells in the synovium of arthritis patients is low, about 0.1 to 0.3% of all T cells investigated. In concordance, T-cell cytokines have proven difficult to detect in synovial samples of arthritis patients (66). Moreover, it was reported that in experimental adjuvant arthritis, the expression of synovial IL-17 is transient and restricted to day 13 after the induction of the disease (4).…”

Section: Discussionmentioning

confidence: 98%

Salmonella enterica Induces Joint Inflammation and Expression of Interleukin-17 in Draining Lymph Nodes Early after Onset of Enterocolitis in Mice

et al. 2012

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Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis

Cited by 57 publications

References 48 publications

A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab

A Prospective Study on Inflammatory Cytokines and Bone Metabolism Mediators in Patients Affected by Rheumatoid and Psoriatic Arthritis treated with Adalimumab

IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17–Triggering Cytokine Production and Limiting Th17 Cell Proliferation

Salmonella enterica Induces Joint Inflammation and Expression of Interleukin-17 in Draining Lymph Nodes Early after Onset of Enterocolitis in Mice

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