Synovial fluid crystals in osteoarthritis

Pa, Gibilisco; Hr, Schumacher; Jl, Hollander; Ka, Soper

doi:10.1002/art.1780280507

Cited by 135 publications

(51 citation statements)

References 9 publications

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“…Hydroxyapatite crystals have been found recently in the synovial fluid of patients with osteoarthritis (OA) (1)(2)(3)(4)(5). It has been suggested that these crystals play a role in the onset of OA (6), in the inflammation (1,(7)(8)(9)(10)(11)(12), or in the progression of joint destruction (2,3,13,14).…”

Section: Hydroxyapatite Deposition In Osteoarthritic Articular Cartilmentioning

confidence: 99%

Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head

Ohira¹,

Ishikawa²

1987

Arthritis & Rheumatism

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Hydroxyapatite crystal deposition in the articular cartilage of the proximal femoral head was examined by using light and electron microscopy and electron probe microanalysis. The hydroxyapatite deposition was significantly more frequent in patients with osteoarthritis (40.7%, 22 of 54) than in control subjects (6.0%, 3 of 50) (P < 0.001). Initial deposition of needle‐like crystals was always seen on or within the electron‐dense, amorphous material around the degenerating hypertrophic chondrocytes. Matrix vesicles were rarely seen in the calcifying areas.

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Section: Hydroxyapatite Deposition In Osteoarthritic Articular Cartilmentioning

confidence: 99%

Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head

Ohira¹,

Ishikawa²

1987

Arthritis & Rheumatism

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“…Osteoarthritis is characterised by a 20-fold increase in subchondral bone turnover and in an increased secretion of alkaline phosphatase (ALP) (Bailey et al, 2004), osteocalcin, osteopontin, IL-6 and IL-8 from subchondral bone explants in osteoarthritis patients (Mathy-Hartert et al, 2008 et al, 2001). Ca-pyrophosphate and Ca-phosphate crystals are frequently found in the synovial fluid and tissues of osteoarthritis patients (Gibilisco et al, 1984;Rosenthal, 2011). However, the role of those hydroxyapatite crystals as aetiological agents, during both initiation and progression of pathogenesis of osteoarthritis, remains controversial (McCarthy and Cheung, 2009;Pritzker, 2009).…”

Section: Introductionmentioning

confidence: 99%

Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate

Wang¹,

Ackermann²,

Tolba³

et al. 2016

eCM

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Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg 2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg 2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble NapolyP. The viscous paste-like material formed, composed of globular microparticles with diameter of 400 nm, strongly promoted the adhesion of chondrocytes and caused a significant upregulation of the expression of the genes encoding collagen type 3A1, as a marker for chondrocyte differentiation, and SOX9, a transcription factor that regulates chondrocyte differentiation and proliferation. The expression level of the collagen type 3A1 gene was also enhanced by exposure of chondrocytes to synovial fluid that was found to contain polyP with a size of about 80 phosphate residues. This stimulatory effect was abolished after pre-incubation of the synovial fluid with the polyP degrading alkaline phosphatase. We propose a strategy for treatment of joint dysfunctions caused by osteoarthritis based on the application of amorphous Mg 2+ -polyP microparticles that prevent calcium crystal formation in the synovial fluid using scavenging Ca -polyP to hyaluronic acid at the cartilage surface.

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“…Various concepts about the association of CC and OA can be resolved into 5 categories, as follows: 1) There is no relationship between CC and OA (2,3,9); 2) CPPD crystal deposi-tion favors the development of OA, or at least its inflammatory manifestations (10); 3) OA and, perhaps, other joint diseases facilitate the deposition of CPPD crystals (4); 4) Chondrocalcinotic arthropathy is a distinct entity that simulates OA (1 1); and 5 ) CC, even at a distance from the affected joint, is in some manner linked to rapid destruction of the OA hip (6). The methods for arriving at these conclusions have varied from histologic to clinical analysis (12,13) and from radiography of specimens (14,15) to analysis of synovial fluid (16,17). CPPD crystals and hydroxyapatite (HA) crystals are frequently present, alone or in combination, in fluid taken from OA knees.…”

mentioning

confidence: 99%

Chondrocalcinosis in surgically resected joints

Sokoloff

Varma

1988

Arthritis & Rheumatism

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To investigate the association between chondrocalcinosis (CC) and osteoarthritis (OA), 338 joint specimens were examined histologically (55 knees and 84 hips surgically resected because of idiopathic OA, 106 control knees obtained postmortem, and 93 fractured hips). The risk for CC in the OA knees was sixfold that of the ageand sex-adjusted control sections. CC occurred much less frequently in the hip than in the knee; the association with OA was less clear-cut. It was not possible to resolve by statistical analysis which of the two pathological processes was the horse and which was the cart.Many published reports address the coexistence of chondrocalcinosis (CC) and osteoarthritis (OA), but there is much controversy about the frequency and significance of the association (1-8). Determining the relationship between the two processes is complicated by the fact that each lesion occurs with a certain frequency in the absence of the other, and both are related to age. The principal calcinotic deposits found are those of calcium pyrophosphate dihydrate (CPPD) crystals. Various concepts about the association of CC and OA can be resolved into 5 categories, as follows: 1) There is no relationship between CC and OA (2,3,9); 2) CPPD crystal deposi-

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Synovial fluid crystals in osteoarthritis

Cited by 135 publications

References 9 publications

Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head

Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head

Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate

Chondrocalcinosis in surgically resected joints

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