Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives

Sousa, Eduardo Branco de; Casado, Priscila Ladeira; Neto, Vivaldo Moura; Duarte, Maria Eugênia Leite; Aguiar, Diego Pinheiro

doi:10.1186/scrt501

Cited by 105 publications

(85 citation statements)

References 52 publications

(85 reference statements)

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“…Later studies showed that the MSCs can be isolated from almost every tissue in the body, such as amniotic and synovial fluids, adipose, dental tissues, umbilical cord, peripheral bloods, dermis, brain, muscle and even tumors (Reynolds and Weiss 1992;Erices et al 2000;Seale and Rudnicki 2000;Zuk et al 2001;Roufosse et al 2004;De Coppi et al 2007;Haniffa et al 2007;Huang et al 2009;Yan et al 2012;de Sousa et al 2014). Although the MSCs have a big therapeutic potential, there are still many problems related to the sudden death of transplanted cells, migration out of transplanted organ, sedimentation into other organs causing unwanted differentiation, inflammation or even secondary cancers.…”

Section: Stem Cells For Tissue Regenerationmentioning

confidence: 97%

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

et al. 2015

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During the last decade biomaterial sciences and tissue engineering have become new scientific fields supplying rising demand of regenerative therapy. Tissue engineering requires consolidation of a broad knowledge of cell biology and modern biotechnology investigating biocompatibility of materials and their application for the reconstruction of damaged organs and tissues. Stem cell-based tissue regeneration started from the direct cell transplantation into damaged tissues or blood vessels. However, it is difficult to track transplanted cells and keep them in one particular place of diseased organ. Recently, new technologies such as cultivation of stem cell on the scaffolds and subsequently their implantation into injured tissue have been extensively developed. Successful tissue regeneration requires scaffolds with particular mechanical stability or biodegradability, appropriate size, surface roughness and porosity to provide a suitable microenvironment for the sufficient cell-cell interaction, cell migration, proliferation and differentiation. Further functioning of implanted cells highly depends on the scaffold pore sizes that play an essential role in nutrient and oxygen diffusion and waste removal. In addition, pore sizes strongly influence cell adhesion, cell-cell interaction and cell transmigration across the membrane depending on the various purposes of tissue regeneration. Therefore, this review will highlight contemporary tendencies in application of non-degradable scaffolds and stem cells in regenerative medicine with a particular focus on the pore sizes significantly affecting final recover of diseased organs.

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Section: Stem Cells For Tissue Regenerationmentioning

confidence: 97%

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

et al. 2015

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“…In general, stem cells are classified based on their source of origin as embryonic stem cells and tissue specific / adult stem cells. Recently, Shinya Yamanaka reported of creating pluripotent stem cells from terminally differentiated fibroblasts [2][3][4][5][6][7][8][9][10][11][12]. Stem cells are also classified based on their differentiation potential -totipotent (early progeny of the zygote up to the eight cell stage of the morula), pluripotent (Inner cell mass of embryo, epiblast), multi/oligopotent (Fetal tissues, membranes, placenta and adult stem cells), bipotent (lymphoid or myeloid stem cells) or unipotent (Muscle stem cells) [13,14].…”

Section: Stem Cellsmentioning

confidence: 99%

Stem Cells and Metallothionein - A Review

2017

IJCRR

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Stem Cells are capable of self renewal and can differentiate into other lineages upon induction with specific growth factors and proteins. Mesenchymal stem cells obtained from various sources like adipose tissue, umbilical cord, bone marrow, umbilical cord blood have been reported to have stem cell characteristic features laid down by International Society for Cellular Therapy. Research so far deals with the differentiation and self renewal properties of stem cells, which needs to be understood further. Metallothionein, is a metal binding protein isolated from equine renal cortex and shown to be present in nearly all of our cells, with differential expression of it's isoforms. Apart from metal binding properties, this protein expression is deregulated in a variety of diseases and other treatment conditions. With respect to cancer biology, this protein expression is studied in almost all cancer types and results indicate pivotal role of this protein in cancer. Certain cancers are associated with up-regulation while some types are associated with down-regulation. The localization of this protein has also reported to change between actively proliferating and normal cells. Given the importance of this protein in cancer biology, the role of this protein in stem cell renewal as well as differentiation is poorly understood. This review discusses about stem cells, -its type and differentiation; metallothioenein -expression, function, review about different cancer types, role in angiogenesis and plausible role of this protein in the self renewal and differentiation of stem cells.

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“…[1][2][3][8][9][10][11][12] These interventions include specific exercise programs, diets and nutritional supplements, and specific cell-based therapies including platelet-rich plasma (PRP) and stem cells as both mitigating agents in disease and the aging process. [102][103][104] The use of stem cells as immune modulators has shown tremendous promise. We now understand that the fate of the stem cells, which we introduce as therapies, is actually of secondary importance to the role they play in eliciting favorable changes in the immune response-primarily by generating anti-inflammatory and thus "antiaging" cytokines and chemokines (Table 1).…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Stem Cells Targeting Inflammation as Potential Anti-aging Strategies and Therapies

Gonzalez¹,

Woynarowski²,

Geffner³

2015

CTTT

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Human aging is associated with a vast array of clinical disorders that all relate to the body's inability to maintain homeostasis. In our bodies, the healing process requires tight control of the acute inflammatory response. When the levels of inflammatory markers such as interleukin-6, tumor necrosis factor alpha, and C-reactive protein are elevated, there is a direct correlation with several chronic diseases of aging such as cardiovascular disease, cognitive decline, and physical disability. Extensive studies have shown strong evidence that elevated levels of these pro-inflammatory mediators may predict disease and disability in the aging population. As there is no cure for aging, a key question is how to modulate the effects of inflammation on aging and how to maintain healthy aging. Stem cells offer alternative approaches for treating various diseases/disorders. The use of stem cells as immune system modulators has shown tremendous promise. Mesenchymal stem cells (MSCs) have specific immunomodulatory properties that may help control inflammation. Several animal studies demonstrate that intravenous infusions of MSCs can decrease the pro-inflammatory response while increasing the anti-inflammatory response. Moreover, human clinical studies using MSCs in autoimmune and other inflammatory diseases have demonstrated modulation of the inflammatory response. Therefore, the use of stem cells as anti-aging therapies may offer many an alternative method of slowing down or deterring several of the detrimental aspects of aging.

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Synovial fluid and synovial membrane mesenchymal stem cells: latest discoveries and therapeutic perspectives

Cited by 105 publications

References 52 publications

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

Stem Cells and Metallothionein - A Review

Stem Cells Targeting Inflammation as Potential Anti-aging Strategies and Therapies

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