Synovial chondromatosis involving multiple joints in rheumatoid arthritis: A case report review of the literature

Bhadu, Danveer; Das, Siddharth Kumar; Dhakad, Urmila; Sharma, Meha; Srivastava, Durgesh; Tripathy, Saumya Ranjan

doi:10.1111/1756-185x.12887

Cited by 10 publications

(10 citation statements)

References 7 publications

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“…Not all cases had detailed clinical and therapeutic information. Four case reports of RA with SC in the English literature had RA duration of 6‐30 years . Three cases with RA had a single joint with SC, and 1 case had multiple joints with SC.…”

Section: Discussionmentioning

confidence: 99%

“…SC has also been reported in association with immune‐mediated inflammatory diseases such as rheumatoid arthritis (RA) and relapsing polychondritis (RP) . However, SC has not been reported in association with ankylosing spondylitis (AS), to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

“…The exact prevalence of primary or secondary SC is unknown, but a few representative case series showed 38 SC cases of all inhabitants (127 000) population in Spain and 20 cases were primary SC, 136 cases of loose bodies in joints over 7 years at Hospital for Special Surgery in New York and 10 cases were primary SC, 4 cases of 107 synovial biopsies over 12 years in Hong Kong,78 of 30 000 orthopedic patients over 32 years at Birmingham Hospital in the UK . Associated SC conditions such as trauma (72 cases) degenerative joint diseases (44 cases) metabolic joint diseases (4 cases) immune inflammatory (9 reported casesand present case) and other diseases (15 cases) were previously reported. AS, ankylosing spondylitis; FOP, fibrodysplasia ossificans progressive; LS, lumbar spondylolisthesis; OC, osteochondrom; OP, osteopoikilosis; PVNS, pigmented villonodular synovitis; RP, relapsing polychondritis…”

Section: Introductionmentioning

confidence: 99%

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Potential utility of anti‐TNF drugs in synovial chondromatosis associated with ankylosing spondylitis

Zhou

et al. 2019

Int J of Rheum Dis

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential utility of anti‐TNF drugs in synovial chondromatosis associated with ankylosing spondylitis

Zhou

et al. 2019

Int J of Rheum Dis

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“…Arthritis is a degenerative disease characterized by joint pain, tenderness, stiffness, swelling, restricted movement and joint deformities ( 1 ). There are a number of different types of arthritis, including rheumatic arthritis, rheumatoid arthritis, osteoarthritis, gouty arthritis, ankylosing spondylitis, reactive arthritis, infectious arthritis and other factor-induced arthritis ( 2 , 3 ). In recent years, the number of osteoarthritis has risen and an increasing number of individuals have been clinically diagnosed with the condition, which presents a serious threat to human health and quality of life ( 4 , 5 ).…”

Section: Introductionmentioning

confidence: 99%

Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells

2018

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Osteonecrosis of the femoral head is an orthopedic disease caused by femoral head damage or insufficient blood supply, which leads to the death of bone cells and bone marrow. Osteonecrosis of the femoral head leads to changes in the structure of the femoral head, femoral head collapse and joint dysfunction. Bone morphogenetic protein-2 (BMP-2) exhibits beneficial effects on bone formation, repair and angiogenesis at the femoral head. In the present study, the therapeutic effects of recombinant human BMP-2 containing an Fc fragment (rBMP-2/Fc) were investigated on a steroid induced mouse model of osteonecrosis of the femoral head. Bone cell viability was used to determine the in vitro effects of rBMP-2/Fc. The therapeutic efficacies of rBMP-2/Fc on mice with osteonecrosis of the femoral head were evaluated using clinical arthritis scores. The expression levels of inflammatory factors in the mice were analyzed by reverse transcription-quantitative polymerase chain reaction. Histological analysis was used to evaluate the effects of rBMP-2/Fc on the femoral head. The results revealed that rBMP-2/Fc treatment significantly increased the IL-6, IL-10, vascular endothelial growth factor and macrophage colony-stimulating factor expression levels in synovial cells compared with the control group (P<0.01). Furthermore, it was observed that rBMP-2/Fc significantly improved the viability and growth of synovial cells (P<0.01) through the nuclear factor (NF)-κB signaling pathway. Treatment with rBMP-2/Fc significantly decreased receptor activator of NF-κB ligand expression levels. Furthermore, in vivo experiments demonstrated that rBMP-2/Fc treatment markedly relieved the arthralgia and damage caused by osteonecrosis of the femoral head. In conclusion, rBMP-2/Fc treatment may be beneficial for articular cartilage repair by the upregulation of angiogenesis factors through the down regulation of the NF-κB signaling pathway in mice with osteonecrosis of the femoral head. This preclinical data suggests that rBMP-2/Fc may be a promising novel agent for treatment of osteonecrosis of the femoral head.

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“…It usually presents unilaterally in large joints. The knee is the joint most commonly involved, but chondromatosis can also manifest in other joints, such as the shoulder, elbow, hip and ankle [ 1 ]. It is uncommon in RA, and only a few cases have been reported.…”

mentioning

confidence: 99%

Synovial chondromatosis of suprapatellar bursa in a case of rheumatoid arthritis

Sureja¹,

Power

2020

Rheumatology Advances in Practice

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Synovial chondromatosis involving multiple joints in rheumatoid arthritis: A case report review of the literature

Cited by 10 publications

References 7 publications

Potential utility of anti‐TNF drugs in synovial chondromatosis associated with ankylosing spondylitis

Potential utility of anti‐TNF drugs in synovial chondromatosis associated with ankylosing spondylitis

Bone morphogenetic protein-2 exhibits therapeutic benefits for osteonecrosis of the femoral head through induction of cartilage and bone cells

Synovial chondromatosis of suprapatellar bursa in a case of rheumatoid arthritis

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