“…309-310. f 2008 Cambridge University Press related to the HR effect at the gene and genomic level. For example, many studies have shown that rates of synonymous evolution increase with the length of coding sequence and levels of synonymous polymorphism are lower in genes with reduced codon bias (Comeron & Aguade, 1996;Moriyama & Powell, 1996;Comeron et al, 1999). Codon usage bias also decreases as the length of coding sequence increases (Moriyama & Powell, 1998;Comeron et al, 1999;Duret & Mouchiroud, 1999).…”