Synergy research: Approaching a new generation of phytopharmaceuticals

Wagner, Hildebert; Ulrich‐Merzenich, G

doi:10.1016/j.phymed.2008.12.018

Cited by 973 publications

(605 citation statements)

References 64 publications

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“…Table III indicates that, in general, the extract of V. zizanioides collected in winter exerted the most promising antimicrobial effects. This fact may be related to the presence of vetiselinenol (3) and other compounds, such as that with t R of 9.55 min, or to the additive and/or synergistic effects (9).…”

Section: Antimicrobial Evaluationmentioning

confidence: 99%

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

et al. 2014

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This paper describes the seasonal phytochemical variation and the antimicrobial potential of V. zizanioides roots collected in Brazil. Considering the high levels of chemical constituents and their biological activity in dichloromethane fraction, the plants were grown in different seasons and the respective dichloromethane fractions were analyzed by gas chromatography-mass spectrometry. The antimicrobial activity was evaluated against several pathogenic microorganisms by determining the minimum inhibitory concentration (MIC) using the agar dilution method. Yields of dichloromethane fractions from plants collected in the autumn and spring occurred in a higher proportion than in other seasons. Khusimol (2) was isolated by column chromatography and identified by NMR and CG-MS, along with other sesquiterpenes, including β-vetivenene (1), vetiselinenol (3), isovalencenol (4), vetivenic acid (5), α-vetivone (6) and β-vetivone (7). Some extracts showed promising antimicrobial effects, with MICs ranging from 31.25 to 500 μg mL -1. Kushimol was slightly active against the tested microorganisms.

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Section: Antimicrobial Evaluationmentioning

confidence: 99%

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

et al. 2014

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“…Numerous theories propose that the interplay and interference of single components in a mixture is the rationale for the advantageous effects of multicomponents. The basic concepts of joint actions and interactions can be summarized as three core processes: addition, synergism, and antagonism [13,14,[24][25][26].…”

Section: Different Types Of Joint Actions Contribute To the Potentiatmentioning

confidence: 99%

“…Potentiation results from additive and synergistic interactions that intensify the potency of a bioactive product [2,14].…”

Section: Botanical Drugmentioning

confidence: 99%

An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field

Gostner¹,

Wrulich²,

Jenny³

et al. 2012

Z Phytother

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“…Another problem can be due to contamination of the raw herbal material with various different adulterants which can increase the toxicity of phytotherapeutic agents [7]. Detailed mechanisms of herbal action still remain unproven, although the health-promoting effect of the herbs seems to rely more on the synergism among different plant components than on the effects of individual compounds [8].…”

Section: Introductionmentioning

confidence: 99%

Qualitative evaluation of composition of the volatile fraction in commercial samples of Cistus incanus L.

Szeremeta

Knaś

Długosz

et al. 2017

Acta Chromatographica

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Summary. The present research is focused on identification of volatile components of different commercial products containing raw herbs of Cistus incanus L. The dried herbal material was hydrodistilled, and the obtained essential oils were analyzed by means of gas chromatography with mass spectrometric detection. Alternatively, the headspace analysis of the volatile sample components was also performed. It was found out that the investigated samples of the C. incanus L. species show a wide variation in terms of quality and quantity of the respective essential oils, which might result in their variable biological activity also. In conclusion, a postulate for standardization of chemical composition of the raw plant material used in therapeutic preparations is formulated.

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Synergy research: Approaching a new generation of phytopharmaceuticals

Cited by 973 publications

References 64 publications

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

Seasonal phytochemical study and antimicrobial potential of Vetiveria zizanioides roots

An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field

Qualitative evaluation of composition of the volatile fraction in commercial samples of Cistus incanus L.

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