Synergy between oligosaccharides and probiotics: From metabolic properties to beneficial effects

Han, Dong; Żulewska, Justyna; Xiong, Ke; Yang, Zhennai

doi:10.1080/10408398.2022.2139218

Cited by 5 publications

(5 citation statements)

References 171 publications

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“…Although most of the studies published are focused on the effect of human milk oligosaccharides (HMOs) present in human milk in the gastrointestinal tract, it is important to highlight that HMOs play a crucial role in supporting the growth of beneficial gut bacteria, possess anti-adhesive effects that reduce the binding of pathogenic bacteria and modulating effects on immunological processes. Even though the diversity of oligosaccharides content of human milk cannot be successfully reproduced on a large scale, the bioactivities of oligosaccharides from bovine and human milk are similar [33,51,52] Therefore, it is possible to assume that the synergy between oligosaccharides from milk and the probiotic L. rhamnosus could have a beneficial impact on oral microbiota. Moreover, the consumption of probiotic supplemented milk could be an advantage for children, since milk is widely used in this age group, and it could effectively contribute to the prevention and even to stop the progression of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Unlocking the potential of probiotic administration in caries management: a systematic review

Lopes,

Gomes,

Mendes

et al. 2024

BMC Oral Health

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Background The use of prebiotics and/or probiotic bacteria with the potential to modulate the oral ecosystem may play an important role in the prevention and management of dental caries. To assess the evidence of the potential of pre/probiotics both in the prevention and treatment of dental caries, we focused on the PICO question “In individuals with caries, after probiotic administration, is there an improvement in outcomes directly related to caries risk and development?“. Methods An extensive systematic search was conducted in electronic databases PubMed, Web of Science, Scopus and Cochrane, to identify articles with relevant data. This systematic review included trials performed in Humans; published in English; including the observation of patients with caries, with clear indication of the probiotic used and measuring the outcomes directly involved with the cariogenic process, including the quantification of bacteria with cariogenic potential. To evaluate the methodological quality of the studies, the critical assessment tool from the Joanna Briggs Institute was used. Results Eight hundred and fifty articles, potentially relevant, were identified. Following PRISMA guidelines 14 articles were included in this systematic review. Outcomes such as reduction of cariogenic microorganism counts, salivary pH, buffer capacity, and caries activity were assessed. The probiotic most often referred with beneficial results in dental caries outcomes is Lacticaseibacillus rhamnosus. Regarding the most used administration vehicle, in studies with positive effects on the caries management, probiotic supplemented milk could be considered the best administration vehicle. Conclusions Evidence suggests a beneficial effect of probiotic supplemented milk (Lacticaseibacillus rhamnosus) as an adjuvant for caries prevention and management. However, comparable evidence is scarce and better designed and comparable studies are needed.

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Section: Discussionmentioning

confidence: 99%

Unlocking the potential of probiotic administration in caries management: a systematic review

Lopes,

Gomes,

Mendes

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…Although most of the studies published are focused on the effect human milk oligosaccharides (HMOs) present in human milk in the gastrointestinal tract, it is important to highlight that HMOs play a crucial role in supporting the growth of bene cial gut bacteria, possess anti-adhesive effects that reduce the binding of pathogenic bacteria and modulating effects on immunological processes. Even though the diversity of oligosaccharides content of human milk cannot be successfully reproduced on a large scale, the bioactivities of oligosaccharides from bovine and human milk are similar (2,26,51). Thus, it is possible to assume that the synergy between oligosaccharides from milk and probiotic L. rhamnosus could have a bene cial impact on oral microbiota.…”

Section: Discussionmentioning

confidence: 99%

Unlocking the potential of probiotic administration in caries management: a systematic review

Lopes

Gomes

Mendes

et al. 2023

Preprint

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Background The use of prebiotics and/or probiotic bacteria with the potential to modulate the oral ecosystem may play an important role in the prevention and management of dental caries. To assess the evidence of the potential of pre/probiotics both in the prevention and treatment of dental caries, and therefore as adjuvant approaches in caries management, we focused on the PICO question “In individuals with caries, after probiotic administration, is there an improvement in outcomes directly related to caries risk and development?". Methods An extensive systematic search was conducted in electronic databases PubMed, Web of Science, Scopus and Cochrane, to identify articles with relevant data. This systematic review included trials complying the following inclusion criteria: studies performed in Humans; published in English; including the observation of patients with caries, with clear indication of the probiotic used and measurement of outcomes directly involved with the cariogenic process, including quantification of bacteria with cariogenic potential. To evaluate methodological quality of the studies, the critical assessment tool Joanna Briggs Institute was used. Results Eight hundred and fifty articles, potentially relevant, were identified. Following PRISMA guidelines 14 articles were included in this systematic review. Outcomes related to improvement of caries risk and development parameters were salivary counts of S. mutans and Lactobacillus, salivary pH and buffer capacity, new caries and caries activity, reduction of the cariogenic organisms content, assessed through sequencing approaches and salivary concentration of antimicrobial peptides. The probiotic most often referred with beneficial results in dental caries outcomes is Lacticaseibacillus rhamnosus being the most recommended to be included in clinical studies related to oral health. Regarding the most used administration vehicle, in studies with positive effects on the caries management, probiotic supplemented milk is considered the best administration vehicle. Conclusions Evidence suggests a beneficial effect of probiotic supplemented milk (Lacticaseibacillus rhamnosus) as an adjuvant for caries prevention and management. However, comparable evidence is scarce and better designed and comparable studies are needed.

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“…Oligosaccharides are not digested and absorbed by the body but are preferentially metabolized by LAB and bifidobacteria (Bali et al., 2015). Most oligosaccharides are utilized by the gut microbiota through transmembrane transporter proteins and endoglycosidases, which contribute to the growth of beneficial bacteria in the intestine (Han et al., 2022). By metabolizing oligosaccharides, gut microbiota can produce beneficial substances, such as SCFAs, tryptophan, and organic acids, which help the host to improve the intestinal barrier, regulate body weight, and balance the immune response (Peredo‐Lovillo et al., 2020).…”

Section: Addition Of Dietary Supplements—diversification Of Functions...mentioning

confidence: 99%

From the past to the future: Fermented milks and their health effects against human diseases

Zhang,

Geng,

Cheng

et al. 2023

Food Frontiers

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The benefits of fermented milk have been known to mankind since the ancient days of civilization. The important role of fermented milk in human nutrition has been well documented through the ages, from the original unpredictable souring of milk caused by the microorganisms inherent in milk to modern microbiological processes, leading to fermented milk with the greater nutritional value produced under controlled conditions. The bioactive peptides synthesized by the microbial degradation of proteins in fermented milk and the addition of supplements, such as probiotics and prebiotics endow them with various physiological functions, including the regulation of the gut microbiota, cholesterol lowering, and immunomodulation, making them potential functional foods that are notable in healthy diets. Here, we summarized the development of fermented milk into four stages and also summarized their impact on health and diseases during different developmental stages. In addition, we described the characteristics and limitations of fermented milk in different eras. Accordingly, we integrated the future trends in the development of fermented milk as functional foods. It is hoped that the efforts to develop the potential of fermented milk as functional foods will help manage the health risks faced by many countries.

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Synergy between oligosaccharides and probiotics: From metabolic properties to beneficial effects

Cited by 5 publications

References 171 publications

Unlocking the potential of probiotic administration in caries management: a systematic review

Unlocking the potential of probiotic administration in caries management: a systematic review

Unlocking the potential of probiotic administration in caries management: a systematic review

From the past to the future: Fermented milks and their health effects against human diseases

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