Synergy between Asbestos and Smoking on Lung

Erren, Thomas C.; Jacobsen, Michael Hviid; Piekarski, Claus

doi:10.1097/00001648-199907000-00011

Cited by 146 publications

(67 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the results cannot be extrapolated directly to the general population, but this occupational group is of special interest for two reasons: 1) this group of people may be at an increased risk of smoking-induced diseases, since persons exposed to asbestos are more likely to be susceptible to the adverse effects of smoking, as has been shown in the case of lung cancer [6]; and 2) workers exposed to asbestos (especially those with pleural plaques) are screened radiologically in many countries [7][8][9] and smoking-related CT findings may thus be a major differential diagnostic problem.…”

Section: Discussionmentioning

confidence: 99%

Effects of tobacco smoking on findings in chest computed tomography among asbestos-exposed workers

Vehmas¹,

Kivisaari²,

Huuskonen³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

Effects of tobacco smoking on findings in chest computed tomography among asbestosexposed workers. T. Vehmas, L. Kivisaari, M.S. Huuskonen, M.S. Jaakkola. #ERS Journals Ltd 2003. ABSTRACT: This study examined the effects of smoking on the findings in chest computed tomography (CT) in 587 asbestos-exposed construction workers (11 females, 576 males, mean age 62 yrs; 18 never-smokers, 406 exsmokers and 163 current smokers). The workers were imaged with spiral CT and high-resolution CT. A total of 13 radiological signs were scored by three radiologists independently. The workers9 medical data, smoking habits and occupational exposures were collected at an interview. The effects of smoking status and smoked pack-yrs (0-87.5) on the CT signs were studied using multivariate analysis adjusted for confounding factors.Smoking increased all emphysema signs and contributed to bronchial wall thickening. Smoking was negatively associated with curvilinear and septal lines as well as with parenchymal bands. In persons who had smoked v10 pack-yrs, smoking was positively related to paraseptal emphysema and to bronchial wall thickening and negatively related to septal lines, subpleural nodules and honeycombing.Smoking was related to several abnormal computed tomography signs even among those with relatively small exposure. Computed tomography can detect changes due to smoking at an early stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of tobacco smoking on findings in chest computed tomography among asbestos-exposed workers

Vehmas¹,

Kivisaari²,

Huuskonen³

et al. 2003

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…The synergy index [S ¼ ERR 11 =ðERR 10 þ ERR 01 Þ] was defined as the ratio of the observed joint excess relative risk of both silicosis and smoking to the sum of the separate estimates (excess relative risk). 37 ERR was the excess relative risk for effects associated with smoking and silicosis on the risk of lung cancer individually (ERR 01 or ERR 10 ) or in combination (ERR 11 ) by subtracting unity from the relevant relative risks. 37 If S equaled one, the joint effect between smoking and silicosis on lung cancer would conform to an additive model.…”

Section: The Assessment Of Multiplicative and Additive Interactionsmentioning

confidence: 99%

“…37 ERR was the excess relative risk for effects associated with smoking and silicosis on the risk of lung cancer individually (ERR 01 or ERR 10 ) or in combination (ERR 11 ) by subtracting unity from the relevant relative risks. 37 If S equaled one, the joint effect between smoking and silicosis on lung cancer would conform to an additive model. In case the joint effect departed from an additive model, then S should not be equal to one.…”

Section: The Assessment Of Multiplicative and Additive Interactionsmentioning

confidence: 99%

Exploring the joint effects of silicosis and smoking on lung cancer risks

Tse

2006

Intl Journal of Cancer

View full text Add to dashboard Cite

Cigarette smoking and silicosis are potential causes of lung cancer among workers exposed to silica dust, but their joint effects are unclear. We explored the possible interactions between silicosis and smoking on lung cancer risks by summarizing data from the published literature. The standardized mortality ratio or standardized incidence ratio reported in each published report was first adjusted using "smoking adjustment factors" to correct for the biased estimation of the expected numbers of lung cancer among smokers and nonsmokers when using general population rates in the indirect standardization process. The ratio of the effect of silicosis on lung cancer risk among smokers to that among nonsmoker was calculated and named the "relative silicosis effect (RSE)". The synergy index was estimated to assess the additive interaction. Metaanalyses were used to obtain the weighed means of the RSE and synergy index. Ten cohort studies were reviewed and combined to yield a weighed RSE of 0.29 (95% CI: 0.20, 0.42), indicating negative risk-ratio multiplication between smoking and silicosis on the lung cancer risk. The combined weighed synergy index was 1.00 (95% CI: 0.79, 1.26), suggesting no departure from additivity. Sensitivity analyses showed that both estimates were quite robust. The independent risk-ratio effect of silicosis on lung cancer in smokers was about 30% of that in nonsmokers, and the joint effects of smoking and silicosis on the risk of lung cancer did not deviate from additivity and hence did not support biological synergism/antagonism.

show abstract

“…In fact, smoking was found to be the main risk factor but its interaction with asbestos was not totally clear (3). Some studies showed a multiplicative effect, whereas other studies suggested an additive model (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Asbestos-related lung cancers: A retrospective clinical and pathological study

Uguen

Dewitte

Marcorelles

et al. 2017

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. Exposure to asbestos results in serious risks of developing mesothelioma and lung cancer. The link between asbestos exposure and lung carcinoma is well established. Nevertheless, precise histopathological data are poorly considered when investigating the asbestos-cancer link in a compensatory approach. In the present study, we aim to describe the features of individuals with compensated lung cancer who were referred to an occupational disease center, regarding occupational exposure to asbestos, smoking history and pathological data. We led a retrospective study of compensated ARLC cases seen in our occupational disease center between 2003 and 2013. A total of 146 men were included (mean age at diagnosis, 63.2 years) of whom approximately 90% were heavy current or former smokers (mean value, 30.4 packs/year). The major industries associated with the lung cancer cases were shipbuilding (69.9%), and building construction (7.5%) in this harbor region. The results of the present study showed that lung upper lobe was most prevalent (61.6%) and an excess of adenocarcinoma was found (45.9%), followed by squamous cell carcinoma (38.4%) as well as thoracic sarcomas (2.1%). Neoplasm was not histologically proven in 6.8% of the cases. Subsequent pathology examinations also reclassified 2 tumors as metastases from esophageal and laryngeal origins. In conclusion, smoking prevention should be encouraged in asbestos-exposed workers as reflected by the number of smokers with asbestos-related lung cancer. Thus, histological data should be considered further to evaluate the potent relationship between asbestos exposure and lung malignancy, especially in a compensatory approach.

show abstract

Synergy between Asbestos and Smoking on Lung

Cited by 146 publications

References 34 publications

Effects of tobacco smoking on findings in chest computed tomography among asbestos-exposed workers

Effects of tobacco smoking on findings in chest computed tomography among asbestos-exposed workers

Exploring the joint effects of silicosis and smoking on lung cancer risks

Asbestos-related lung cancers: A retrospective clinical and pathological study

Contact Info

Product

Resources

About