Synergy based Extracts of Medicinal Plants: Future Antimicrobials to Combat Multidrug Resistance

Abstract

The use of herbal medicines and supplements in the last thirty years has increased enormously. Herbal medication has demonstrated promising and effective potential against various diseases. Herbal and phytoconstituent medications are gaining popularity globally and many people are adopting herbal remedies to deal with different health issues. The indiscriminate use of antibiotics, due to the development of antimicrobial resistance, poses an unprecedented problem for human civilization. Bacterial infections are difficult to cure because of the propensity of microbes to acquire resistance to a wide range of antimicrobial drugs. New compounds are being explored and quantified for possible antibacterial activity with little or no side effects. Researchers are investigating the range of therapeutic plants mentioned in Unani, Ayurveda, and Siddha around the globe. Known and commonly acclaimed global databases such as PubMed, Research Gate, Science Direct, Google Scholar, were searched using different search strings such as Indian medicinal plants, multidrug resistance (MDR), thin layer chromatography (TLC), antimicrobials, and Synergism were used in diverse combinations to reclaim numerous citations associated with this area. Thus, the current review aims to shed a light on the information of medicinal plants as a potential foundation of herbal drugs and elucidate how synergism and TLC bioautography plays a crucial role in finding antimicrobial compounds.

Chemical Constituents, Antioxidant Potential, and Antimicrobial Efficacy of Pimpinella anisum Extracts against Multidrug-Resistant Bacteria

“…Nevertheless, in addition to intrinsic antibacterial agents [2], certain medicinal plants also generate inhibitors of multidrug resistance [3], which are capable of enhancing the activity of antibiotics against multidrug-resistant bacteria [4]. As a result of this finding, crude extracts were examined for potential synergistic interactions with common antibiotics against resistant bacteria, opening the door for the discovery of plant-based multidrug resistance inhibitors [5].…”

Chemical Composition, Antibacterial and Antibiofilm Actions of Oregano (Origanum vulgare subsp. hirtum) Essential Oil against Salmonella Typhimurium and Listeria monocytogenes

“…The increased tolerance and resistance of several pathogenic bacteria to antibiotics and/or disinfectants has led to the continuous search for novel antimicrobial agents [16][17][18]. Plants may be a promising source for such compounds mainly due to their great biological diversity, abundance, and safe and ecofriendly nature [19,20]. In the past few years, there have been numerous studies published on the antimicrobial and antibiofilm actions of various EOs including those of oregano species [21][22][23][24].…”