Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes

Hoegen, Paul von

doi:10.1016/0165-2478(95)00065-4

Cited by 40 publications

(16 citation statements)

References 16 publications

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“…20 Our previous experimental studies of gene therapy prompted us to examine antitumor immunity in immunocompetent animals, so we treated syngeneic intracerebral gliomas with the murine IFN-␤ gene.…”

Section: Discussionmentioning

confidence: 99%

“…In general, MHC class I-restricted CD8 + T cells are considered important to the antitumor immune response. Primary brain tumors including gliomas are not highly immunogenic, but von Hoegen et al 20 have demonstrated that type I-IFN, especially IFN-␤, induces an immune response even against poorly immunogenic tumors. We administered recombinant muIFN-␤ intratumorally on day 4 after tumor transplantation, but it failed to induce an immune response.…”

Section: Discussionmentioning

confidence: 99%

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Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse

et al. 1999

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Cationic liposomes containing the human interferon-␤ added murine IFN-␤. In in vivo experiments, intratumoral (IFN-␤) gene induce marked growth inhibition in human gliadministration of liposomes containing the murine IFN-␤ oma cells. In vivo experiments using an human glioma gene resulted in a 16-fold reduction in the mean volume of implanted into the brains of nude mice have demonstrated residual gliomas in the brains of C57BL/6 mice and massa definite growth-inhibitory effect, achieving complete ive infiltration of cytotoxic T lymphocytes (CTL) within the tumor regression with multiple intratumoral injections of the residual tumor, while few CTL were infiltrated in controls gene. However, nude mouse studies are inadequate to including murine IFN-␤, empty liposomes, naked plasmid evaluate antitumor effects fully, especially those related to expressing murine IFN-␤, and liposomes containing ␤-activation of the host immune response. This article aimed galactosidase gene. In addition, 40% of mice treated with to investigate antitumor effects and immune response actiliposomes containing the murine IFN-␤ gene were comvation by murine IFN-␤ gene transfer in syngeneic mice.pletely cured. These findings indicated that activation of In vitro experiments demonstrated a stronger growth-inhibicellular immunity participates in antitumor effects in vivo tory effect of liposomes containing the murine IFN-␤ gene together with direct effects of the IFN-␤ gene. on a GL261 mouse glioma cell line than exogenously

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse

et al. 1999

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“…Depending on experimental conditions and IFN concentrations, IFN-␣/␤ has been shown to cause either enhanced antigen-specific T-cell proliferation and CTL activity or T-cell loss and inhibition of CTL activity (6,9,10,19,45). High levels of IFN in vivo can lead to diminished bone marrow function and severe leukopenia (3).…”

Section: Discussionmentioning

confidence: 99%

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

McNally

Zarozinski

Lin

et al. 2001

J Virol

184

233

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Experiments designed to distinguish virus-specific from non-virus-specific T cells showed that bystander T cells underwent apoptosis and substantial attrition in the wake of a strong T-cell response. Memory CD8 T cells (CD8 ؉ CD44 hi ) were most affected. During acute viral infection, transgenic T cells that were clearly defined as non-virus specific decreased in number and showed an increase in apoptosis. Also, use of lymphocytic choriomeningitis virus (LCMV) carrier mice, which lack LCMV-specific T cells, showed a significant decline in non-virus-specific memory CD8 T cells that correlated to an increase in apoptosis in response to the proliferation of adoptively transferred virus-specific T cells. Attrition of T cells early during infection correlated with the alpha/beta interferon (IFN-␣/␤) peak, and the IFN inducer poly(I:C) caused apoptosis and attrition of CD8 ؉ CD44 hi T cells in normal mice but not in IFN-␣/␤ receptor-deficient mice. Apoptotic attrition of bystander T cells may make room for the antigen-specific expansion of T cells during infection and may, in part, account for the loss of T-cell memory that occurs when the host undergoes subsequent infections.

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“…For a long time, the importance of the effects of type I IFN on the immune system remained poorly considered (6). In recent years, however, some reports have shown that these cytokines affect the differentiation, survival, and function of immune cells, including T cells (7)(8)(9)(10)(11)(12)(13)(14)(15) and dendritic cells (DCs) 3 (16 -20) and efficiently enhance a primary Ab response (21). In a recent study it was shown that immunization of mice with chicken ␥-globulin in the presence of type I IFN results in the generation of a potent primary immune response, characterized by an isotype switching toward IgG2a Abs (21).…”

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confidence: 99%

Type I IFN as a Natural Adjuvant for a Protective Immune Response: Lessons from the Influenza Vaccine Model

Proietti

Bracci

Puzelli

et al. 2002

The Journal of Immunology

200

150

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The identification of natural adjuvants capable of selectively promoting an efficient immune response against infectious agents would represent an important advance in immunology, with direct implications for vaccine development, whose progress is generally hampered by the difficulties in defining powerful synthetic adjuvants suitable for clinical use. Here, we demonstrate that endogenous type I IFN is necessary for the Th1 type of immune response induced by typical adjuvants in mice and that IFN itself is an unexpectedly powerful adjuvant when administered with the human influenza vaccine, for inducing IgG2a and IgA production and conferring protection from virus challenge. The finding that these cytokines, currently used in patients, are necessary for full expression of adjuvant activity and are sufficient for the generation of a protective immune response opens new perspectives in understanding the basis of immunity and in vaccine development.

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Synergistic role of type I interferons in the induction of protective cytotoxic T lymphocytes

Cited by 40 publications

References 16 publications

Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse

Antitumor effect and cellular immunity activation by murine interferon-β gene transfer against intracerebral glioma in mouse

Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

Type I IFN as a Natural Adjuvant for a Protective Immune Response: Lessons from the Influenza Vaccine Model

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