Synergistic renoprotective effects of sesame oil and erythropoietin on ischemic kidney injury after renal transplantation

Abstract

In this study, we evaluated the combined therapeutic efficacy of erythropoietin (a hematopoietic hormone produced by the fetal liver and kidney in response to inflammation and apoptosis) and sesame oil (from Sesamum indicum L.) on ischemic kidney injury following kidney transplantation in a rat model. Rats were assigned to the following groups: sham, control, 1000 U/kg erythropoietin, 1 mL/kg sesame oil, 1000 U/kg erythropoietin + 1 mL/kg sesame oil, and positive control. We measured the levels of blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), lipid peroxidation, reactive oxygen species (ROS), reduced glutathione (GSH), antioxidant enzymes, and proinflammatory markers and performed renal histopathological evaluation. The combined erythropoietin and sesame oil treatment significantly reduced BUN, ALT, creatinine, lipid peroxidation, ROS, and proinflammatory markers and GSH and antioxidant enzyme levels. Histopathological examination showed that the combined erythropoietin and sesame oil treatment significantly reduced necrosis. Therefore, combined treatment of sesame oil and erythropoietin may represent an effective therapeutic approach against ischemic kidney injury after kidney transplantation.

The Efficacy and Safety of Mizoribine versus Mycophenolate Mofetil for the Treatment of Renal Transplantation: A Systematic Review and Meta-Analysis

“…(1) MZR has an active structure similar to the antiviral drug ribavirin, so it has a certain inhibitory effect on a variety of viruses, while Japanese scholars believe that MZR may also have a certain inhibitory effect on BK virus (BKV) in the diagnosis and treatment of patients with BKV urine after renal transplantation (2) Early Brennan and other scholars have verified that MMF immunosuppressive regimen is one of the risk factors of BKV reactivation (3) e immunosuppressive effect of low-dose (1-3 mg/ kg/d) MZR after renal transplantation is weaker than that of MMF, while high-dose (5-6 mg/kg/d) MZR is considered to provide the same immunosuppressive intensity as MMF erefore, in theory, when MMF is converted to MZR, it can not only rely on its anti-BKV activity but also increase the self-specific immune effect against BKV due to the decrease of immunosuppression so as to comprehensively inhibit the replication of BKV [31][32][33]. In our paper, the meta-analysis was used to evaluate the efficacy and safety of MZR and MMF in renal transplant recipients.…”