Synergistic removal of pharmaceuticals and antibiotic resistance from ultrafiltered WWTP effluent: Free-floating ARGs exceptionally susceptible to degradation

Gajdoš, Stanislav; Zuzáková, Jana; Pacholská, Tamara; Kužel, Vojtěch; Karpíšek, Ivan; Bachmannová, Ch.; Šturmová, Rebecca; Bindzar, J.; Smrčková, Štěpánka; Sýkorová, Zuzana; Srb, Martin; Šmejkalová, Pavla; Vejmelková, Dana; Kouba, Vojtěch

doi:10.1016/j.jenvman.2023.117861

Cited by 10 publications

(2 citation statements)

References 63 publications

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“…From the engineering and agro-industrial point of view, removing pharmaceutics and antibiotic resistance genes (ARGs) from water, soil, animal feed, and manure would greatly help reduce antibiotic resistance. This feature can be achieved by combining metalbased filtering systems [62,63], biological and biotechnological agents [64,65], and better maintenance and management [66,67]; a remarkable, somewhat different example in the field is brought up by the use of cultivated meat, which not only drastically reduces CO 2 , biological, and chemical waste with respect to farms but also almost deletes the need for antibiotics [68,69].…”

Section: Polymixinsmentioning

confidence: 99%

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Nicolosi,

Petronio Petronio,

Russo

et al. 2023

IJMS

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The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains, usually associated with poorer patient outcomes and higher costs. In order to preserve the usefulness of these life-saving drugs, it is crucial to use them appropriately, as also recommended by the WHO. Moreover, innovative, safe, and more effective approaches are being investigated, aiming to revise drug treatments to improve their pharmacokinetics and distribution and to reduce the onset of drug resistance. Globally, to reduce the burden of antimicrobial resistance (AMR), guidelines and indications have been developed over time, aimed at narrowing the use and diminishing the environmental spread of these life-saving molecules by optimizing prescriptions, dosage, and times of use, as well as investing resources into obtaining innovative formulations with better pharmacokinetics, pharmacodynamics, and therapeutic results. This has led to the development of new nano-formulations as drug delivery vehicles, characterized by unique structural properties, biocompatible natures, and targeted activities such as state-of-the-art phospholipid particles generally grouped as liposomes, virosomes, and functionalized exosomes, which represent an attractive and innovative delivery approach. Liposomes and virosomes are chemically synthesized carriers that utilize phospholipids whose nature is predetermined based on their use, with a long track record as drug delivery systems. Exosomes are vesicles naturally released by cells, which utilize the lipids present in their cellular membranes only, and therefore, are highly biocompatible, with investigations as a delivery system having a more recent origin. This review will summarize the state of the art on microvesicle research, liposomes, virosomes, and exosomes, as useful and effective tools to tackle the threat of antibiotic resistance.

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Section: Polymixinsmentioning

confidence: 99%

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Nicolosi,

Petronio Petronio,

Russo

et al. 2023

IJMS

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“…According to several reports, surface water and reclaimed wastewater used for irrigation are signi cant sources of ARBs and ARGs 16 . Due to inadequate removal of ARGs, which are crucial in the growth of extremely unfavourable drug-resistant superbugs, reuse of WWTP e uents may be harmful to human health 17 .…”

Section: Introductionmentioning

confidence: 99%

Sewage reclamation process as multifactorial public health risk concern: a longitudinal study.

Cuevas-Ferrando,

Girón-Guzmán,

Sánchez-Alberola

et al. 2024

Preprint

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This year-long research analysed emerging risks in influent, effluent wastewaters and biosolids from six wastewater treatment plants in Spain's Valencian Region. Specifically, it focused on human enteric and respiratory viruses, bacterial and viral faecal contamination indicators, extended spectrum beta-lactamases-producing Escherichia coli and antibiotic resistance genes. Additionally, particles and microplastics in biosolid and wastewater samples were assessed. Human enteric viruses were prevalent in influent wastewater, with limited post-treatment reduction. Wastewater treatment effectively eliminated respiratory viruses, except for low levels of SARS-CoV-2 in effluent and biosolid samples, suggesting minimal public health risk. Antibiotic resistance genes and microplastics were persistently found in effluent and biosolids, thus indicating treatment inefficiencies and potential environmental dissemination. This multifaced research sheds light on diverse contaminants present after water reclamation, emphasizing the interconnectedness of human, animal, and environmental health in wastewater management. It underscores the need for a One Health approach to address the United Nations Sustainable Development Goals.

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Removing antibiotic resistance genes through the synergistic effect of hydroxyl radical and hypochlorite radical generated in a CeO2@CNT electrified membrane – NaClO system

Wang

Hou

et al. 2023

Chemical Engineering Journal

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Synergistic removal of pharmaceuticals and antibiotic resistance from ultrafiltered WWTP effluent: Free-floating ARGs exceptionally susceptible to degradation

Cited by 10 publications

References 63 publications

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Sewage reclamation process as multifactorial public health risk concern: a longitudinal study.

Removing antibiotic resistance genes through the synergistic effect of hydroxyl radical and hypochlorite radical generated in a CeO2@CNT electrified membrane – NaClO system

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