Synergistic protective effects of ceftriaxone and ascorbic acid against subacute deltamethrin-induced nephrotoxicity in rats

Abstract

Deltamethrin (DLM) is a synthetic class II pyrethroid acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid against DLM-induced renal injury in male Wistar albino rats. DLM-treated animals revealed significant alterations in serum biochemical parameters related to renal injury; urea, uric acid and creatinine. There was a significant increase in renal lipid peroxidation and a significant inhibition in antioxidant biomarkers. Moreover, DLM significantly reduced serum acetylcholinesterase (AChE) activity. In addition, It induced serum and kidney tumor necrosis factor-α (TNF-α). Both ceftriaxone and ascorbic acid protect against DLM-induced biochemical alterations in serum and renal tissue when used alone or in combination along with DLM-intoxication. Furthermore, both ceftriaxone and ascorbic acid produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or ascorbic acid administration able to minimize the toxic effects of DLM through their free radical-scavenging and potent antioxidant activity.

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

“…Avidin‐horseradish peroxidase conjugate was used to oxidize 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic destructive), which made a chromogen whose obsession was comparing to the centralization of the cytokine being assessed. The estimations were measured at a wavelength of 405 nm through spectrophotometry …”

Unravelling Pathophysiology of Crystalline Nephropathy in Ceftriaxone-Associated Acute Kidney Injury: A Cellular Proteomic Approach

“…In addition, further studies on the effects of “soluble” ceftriaxone on renal tubular cells would be of interest to better understand the pathophysiology of ceftriaxone-associated AKI. Note that the soluble ceftriaxone exhibited non-antimicrobial protective effects in models of neurological diseases, that is, Alexander’s disease [33, 34], Parkinson’s disease [35], and early brain injury after subarachnoid hemorrhage [36] and nephrotoxicity due to deltamethrin insecticide [37] and cadmium metal [38]. It is suspected that renal tubular cells would recognize and respond to soluble ceftriaxone and Cef-Ca crystals differently, and possession of this knowledge may have translational potentials in pediatric precision medicine.…”

Modulatory effects of vitamin C on biochemical and oxidative changes induced by acute exposure to diazinon in rat various tissues: Prophylactic and therapeutic roles

“…Vitamin C can also restore the antioxidant abilities of vitamin E, suggesting that one of its major functions is to recycle the tocopheroxyl radical (Mirvaghefi, Ali, & Poorbagher, ). Vitamin C ameliorated oxidative stress induced by various toxicants such as chlorpyrifos, deltamethrin and cisplatin (Abdel‐Daim et al, ; Abdel‐Daim & El‐Ghoneimy, ; Ambali, Onukak, et al, ). In addition, studies have showed the protective effect of vitamin C against DZN‐induced oxidative stress in fish blood (Mirvaghefi et al, ) and rat kidney (Abdel‐Daim, ) for 4 weeks and in rat brain after 24 hr (Yilmaz, Yilmaz, & Altuntas, ).…”