Synergistic photodynamic and photothermal therapy of BODIPY-conjugated hyaluronic acid nanoparticles

Chen, Bowen; Cao, Jie; Zhang, Kebiao; Zhang, Yuan-Ning; Lü, Jiaju; Iqbal, M. Zubair; Zhang, Quan; Kong, Xiangdong

doi:10.1080/09205063.2021.1954138

Cited by 16 publications

(13 citation statements)

References 48 publications

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“…A promising area of research is using a combination of phototherapy methods, namely, photothermal and photodynamic treatment for antitumor therapy. The use of laser radiation in both methods, acceleration of photochemical reactions during hyperthermia, synergistic effects on tumor blood vessels, time-difference of the therapeutic effects of PPT and PDT, increased thermosensitivity of cells in hypoxic conditions caused by the photochemical reaction-determine the effectiveness of combined therapy method [197][198][199]. Compared with conventional chemotherapy, combined phototherapy has significant advantages such as low invasiveness, high spatiotemporal selectivity, and rapid post-operation recovery [200,201].…”

Section: The Nanoparticle Application For Antitumor Therapymentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

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Cancer remains one of the leading causes of death in the world. For a number of neoplasms, the efficiency of conventional chemo- and radiation therapies is insufficient because of drug resistance and marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored in tumor treatment. However, despite attractive promises, the current PPT status is limited by laboratory experiments, academic papers, and only a few preclinical studies. Unfortunately, most nanoformulations still share a similar fate: great laboratory promises and fair preclinical trials. This review discusses the current challenges and prospects of plasmonic nanomedicine based on PPT and photodynamic therapy (PDT). We start with consideration of the fundamental principles underlying plasmonic properties of AuNPs to tune their plasmon resonance for the desired NIR-I, NIR-2, and SWIR optical windows. The basic principles for simulation of optical cross-sections and plasmonic heating under CW and pulsed irradiation are discussed. Then, we consider the state-of-the-art methods for wet chemical synthesis of the most popular PPPT AuNPs such as silica/gold nanoshells, Au nanostars, nanorods, and nanocages. The photothermal efficiencies of these nanoparticles are compared, and their applications to current nanomedicine are shortly discussed. In a separate section, we discuss the fabrication of gold and other nanoparticles by the pulsed laser ablation in liquid method. The second part of the review is devoted to our recent experimental results on laser-activated interaction of AuNPs with tumor and healthy tissues and current achievements of other research groups in this application area. The unresolved issues of PPT are the significant accumulation of AuNPs in the organs of the mononuclear phagocyte system, causing potential toxic effects of nanoparticles, and the possibility of tumor recurrence due to the presence of survived tumor cells. The prospective ways of solving these problems are discussed, including developing combined antitumor therapy based on combined PPT and PDT. In the conclusion section, we summarize the most urgent needs of current PPT-based nanomedicine.

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Section: The Nanoparticle Application For Antitumor Therapymentioning

confidence: 99%

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Bucharskaya

Khlebtsov

et al. 2022

Materials

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“…After 24 h, the cells were washed and further incubated with 100 μL of complete medium containing either 2Py-BDP@Lipos or 3Py-BDP@Lipos at different PS concentrations for 12 h. For the irradiated groups, the 4T1 cancer cells were directly exposed to laser irradiation (660 nm, 33 mW/cm 2 ) for 10 min. After another 12 h of incubation, the cytotoxicity of the samples was investigated using the MTT assay . Finally, the corresponding absorbance (CA) of each well at 570 nm was monitored using a microplate reader (SpectraMax Plus 384).…”

Section: Experimental Sectionmentioning

confidence: 99%

Mitochondria-Targeted Photodynamic Cancer Therapy of Nanoscale Liposome-Encapsulating Boron Dipyrromethene Photosensitizers Conjugated with Pyridine Cations

Cao

Zhang

Shi

et al. 2022

ACS Appl. Nano Mater.

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The development and use of mitochondria-targeted photosensitizers (PSs) hold great promise for enhancing the therapeutic efficacy and minimizing the side effects of photodynamic therapy (PDT). Although many studies have shown that coupling lipophilic cations to PSs facilitates their targeting to mitochondria, this process leads to a nonspecific distribution of PSs in the body and undesired systemic toxicity. Herein, three boron dipyrromethene (BODIPY) PSs conjugated with pyridine cations (1Py-BDP, 2Py-BDP, and 3Py-BDP) were synthesized to systematically evaluate the effects of the cationic pyridine number on the cytotoxicity and mitochondria-targeting property of the PSs for precise cancer PDT. To increase their stability in biological systems, these BODIPY PSs were encapsulated with an amphiphilic polymer (DSPE-mPEG2000) to afford PS-loaded liposomal nanoparticles designated 1Py-BDP@Lipos, 2Py-BDP@Lipos, and 3Py-BDP@Lipos. The results demonstrated that 2Py-BDP@Lipos showed higher efficiency for targeted delivery of the PSs to mitochondria compared with 1Py-BDP@Lipos and 3Py-BDP@Lipos. Moreover, the cytotoxicity of these BODIPY PSs was enhanced with the increase in the number of pyridine cations. In vivo results confirmed that liposomal encapsulation enhanced the tumor accumulation and retention of 2Py-BDP, which could effectively inhibit tumor growth under 660 nm laser irradiation. This study demonstrates that the conjugation of two pyridine cations with BODIPY PSs leads to improved targeting to mitochondria while maintaining low toxicity, thus facilitating the design of mitochondria-targeted PSs for in vivo PDT applications.

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“…Over the years, different types of nanomaterials with the potential to mediate such photothermal/photodynamic effects have been developed: gold nanospheres [ 40 ], gold nanorods [ 41 ], platinum NPs [ 42 , 43 ], and polydopamine (PDA) NPs [ 44 , 45 ]. Alternatively, hydrophobic small-molecules with photothermal/photodynamic capabilities (e.g., zinc(II) phthalocyanines [ 46 , 47 ], BODIPY™ [ 48 , 49 , 50 ], chlorin e6 [ 51 , 52 , 53 ]) have also been encapsulated in nanomaterials in order to enhance their solubility, cytocompatibility, and/or tumor uptake. Ideally, the nanostructures are exposed to laser light with a wavelength that is similar to the wavelength of the nanostructures’ maximum absorption.…”

Section: Introductionmentioning

confidence: 99%

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

et al. 2022

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The development of strategies capable of eliminating metastasized cancer cells and preventing tumor recurrence is an exciting and extremely important area of research. In this regard, therapeutic approaches that explore the synergies between nanomaterial-mediated phototherapies and immunostimulants/immune checkpoint inhibitors have been yielding remarkable results in pre-clinical cancer models. These nanomaterials can accumulate in tumors and trigger, after irradiation of the primary tumor with near infrared light, a localized temperature increase and/or reactive oxygen species. These effects caused damage in cancer cells at the primary site and can also (i) relieve tumor hypoxia, (ii) release tumor-associated antigens and danger-associated molecular patterns, and (iii) induced a pro-inflammatory response. Such events will then synergize with the activity of immunostimulants and immune checkpoint inhibitors, paving the way for strong T cell responses against metastasized cancer cells and the creation of immune memory. Among the different nanomaterials aimed for cancer immuno-phototherapy, those incorporating near infrared-absorbing heptamethine cyanines (Indocyanine Green, IR775, IR780, IR797, IR820) have been showing promising results due to their multifunctionality, safety, and straightforward formulation. In this review, combined approaches based on phototherapies mediated by heptamethine cyanine-loaded nanomaterials and immunostimulants/immune checkpoint inhibitor actions are analyzed, focusing on their ability to modulate the action of the different immune system cells, eliminate metastasized cancer cells, and prevent tumor recurrence.

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Synergistic photodynamic and photothermal therapy of BODIPY-conjugated hyaluronic acid nanoparticles

Cited by 16 publications

References 48 publications

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects

Mitochondria-Targeted Photodynamic Cancer Therapy of Nanoscale Liposome-Encapsulating Boron Dipyrromethene Photosensitizers Conjugated with Pyridine Cations

Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

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