Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

Singh, Parbeen; Youden, Brian; Yang, Yikun; Chen, Yongli; Carrier, Andrew; Cui, Shufen; Oakes, Ken D.; Servos, Mark R.; Jiang, Runqing; Zhang, Xu

doi:10.1021/acsami.1c12235

Cited by 29 publications

(19 citation statements)

References 49 publications

(67 reference statements)

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“…649−652 An investigation of the peroxidase-like activity of CuS nanorods by Guan et al found that the nanorod activities were concentrated on the particle surface, with negligible activity resulting from leached Cu 2+ ions. 652,653 The authors hypothesized that absorbed H 2 O 2 /HO 2 − reacts with surface-bound Cu 2+ to generate • OH, which are stabilized via partial electron exchange interactions. The bound • OH could then oxidize nearby molecules to induce cellular damage.…”

Section: Phase Iii: Molecular Mechanisms Of Activitymentioning

confidence: 99%

“…701,702 In our own work, we have identified that chloride ions, which vary dramatically in concentration inside and outside cells, can accelerate the production of ROS by Cubased NPs. 652,703 Overall, most inorganic nanomedicines possess some inherent chemical reactivity, which can be enhanced or inhibited in different physiological conditions. These conditions are determined in prior Phases and can be described using feedback parameters, such as tissue and subcellular location.…”

Section: Phase Iii: Molecular Mechanisms Of Activitymentioning

confidence: 99%

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A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies

et al. 2022

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Despite their clinical success in drug delivery applications, the potential of theranostic nanomedicines is hampered by mechanistic uncertainty and a lack of scienceinformed regulatory guidance. Both the therapeutic efficacy and the toxicity of nanoformulations are tightly controlled by the complex interplay of the nanoparticle's physicochemical properties and the individual patient/tumor biology; however, it can be difficult to correlate such information with observed outcomes. Additionally, as nanomedicine research attempts to gradually move away from large-scale animal testing, the need for computer-assisted solutions for evaluation will increase. Such models will depend on a clear understanding of structure− activity relationships. This review provides a comprehensive overview of the field of cancer nanomedicine and provides a knowledge framework and foundational interaction maps that can facilitate future research, assessments, and regulation. By forming three complementary maps profiling nanobio interactions and pathways at different levels of biological complexity, a clear picture of a nanoparticle's journey through the body and the therapeutic and adverse consequences of each potential interaction are presented.

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Section: Phase Iii: Molecular Mechanisms Of Activitymentioning

confidence: 99%

Section: Phase Iii: Molecular Mechanisms Of Activitymentioning

confidence: 99%

A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies

et al. 2022

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“…In 2005, scientists found that the production of reactive oxygen and nitrogen species was a fundamental element influencing the toxic effects and carcinogenicity of trace metals, including copper ( Valko et al, 2005 ). In addition, the Fenton reaction, which generates superoxide radicals and hydroxyl radicals, is involved in the influence of copper on living organisms ( Singh et al, 2021 ). Previous studies have shown that unbalanced intracellular copper levels influence tumorigenesis and the growth and metastasis of tumors, causing irreversible damage.…”

Section: Introductionmentioning

confidence: 99%

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Liu

Lu²,

Dai³

et al. 2022

Front. Genet.

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Background: Cuproptosis is a novel type of cell death induced by copper. Cuproptosis-associated genes play a crucial part in oncogenesis and the growth and metastasis of tumors. However, the correlations among cuproptosis-associated genes, overall survival, the tumor microenvironment, and drug sensitivity remain unclear. Therefore, we performed an analysis of cuproptosis-associated genes across cancers.Methods: We downloaded RNA sequence expression data, clinical and survival data, stemness score data, and immune subtype data of cuproptosis-associated genes from the UCSC Xena. Next, we conducted differential analysis, expression analysis and correlation analysis across cancers with various R packages. Moreover, survival analysis and Cox hazard analysis were conducted to investigate the relationships between cuproptosis-associated genes and survival outcomes in various cancer types. Finally, we also analyzed the relationship among the levels of cuproptosis-associated genes across cancers, immune types, the tumor microenvironment, stemness scores, and drug sensitivity. Expression validation of cuproptosis-associated genes in renal cancer and normal tissues by immunohistochemical staining.Results: We found that 10 cuproptosis-associated genes (FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, and CDKN2A) were differently expressed in 18 tumors and normal tissues. Survival outcomes showed that cuproptosis-associated genes had prognostic value in various cancer types. Moreover, we identified that cuproptosis-associated genes had different levels in six immune subtypes. The study also indicated that the levels of most cuproptosis-associated genes were positively correlated with the RNAss and DNAss. FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, and PDHB were negatively correlated with immune scores and ESTIMATE scores. In addition, we identified the top 16 drugs strongly sensitivity to cuproptosis-associated genes according to the correlation coefficient. Finally, we also found that cuproptosis-associated genes were significantly correlated with immune subtype, clinical features, the tumor microenvironment, and drug sensitivity in Kidney renal clear cell carcinoma. And the results of immunohistochemical staining analysis was very consistent with the previous analysis.Conclusion: We performed an overall analysis to uncover the roles of cuproptosis-associated genes in differential expression, survival outcomes, immune subtypes, the tumor microenvironment, stemness scores, and cancer drug sensitivity across cancers.

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“…To address the above problems, herein, a chemoenzymatic cascade reaction using glucose oxidase (GOD) and Fe 3 O 4 nanoparticles as catalysts was proposed for foulant degradation and polyamide NF membrane cleaning. Specifically, GOD enzymatic reaction was initiated by glucose, and the generated gluconic acid would decrease the pH of the system, which was supposed to improve the Fe 3 O 4 -catalyzed Fenton reaction with the produced H 2 O 2 . , The advantages of such a chemoenzymatic cascade reaction over the single enzymatic/Fenton reaction in BPA and MB degradation have been explored. The efficiency and reusability of the cascade reaction for polyamide NF membrane cleaning and its effect on membrane performance were investigated.…”

Section: Introductionmentioning

confidence: 99%

Chemoenzymatic Cascade Reaction for Green Cleaning of Polyamide Nanofiltration Membrane

Zhang

Wan

et al. 2022

ACS Appl. Mater. Interfaces

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Chemical cleaning is indispensable for the sustainable operation of nanofiltration (NF) in wastewater treatment. However, the common chemical cleaning methods are plagued by low cleaning efficiency, high chemical consumption, and separation performance deterioration. In this work, a chemoenzymatic cascade reaction is proposed for pollutant degradation and polyamide NF membrane cleaning. Glucose oxidase (GOD) enzymatic reaction in this cascade system produces hydrogen peroxide (H2O2) and gluconic acid to trigger the oxidation of foulants by Fe3O4-catalyzed Fenton reaction. By virtue of the microenvironment (pH and H2O2 concentration) engineering and substrate enrichments, this chemoenzymatic cascade reaction (GOD–Fe3O4) exhibits a favorable degradation efficiency for bisphenol A and methyl blue (MB). Thanks to the strong oxidizing degradation, the water flux of the NF10 membrane fouled by MB is almost completely recovered (∼95.8%) after a 3-cycle fouling/cleaning experiment. Meanwhile, the chemoenzymatic cascade reaction improves the applicability of the Fenton reaction in polyamide NF membrane cleaning because it prevents the membrane from damaging by high concentration of H2O2 and inhibits the secondary fouling caused by ferric hydroxide precipitates. By immobilizing GOD on the aminated Fe3O4 nanoparticles, a reusable cleaning agent is prepared for highly efficient membrane cleaning. This chemoenzymatic cascade reaction without the addition of an acid/base/oxidant provides a promising candidate for sustainable and cost-effective cleaning for the polyamide NF membrane.

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Synergistic Multimodal Cancer Therapy Using Glucose Oxidase@CuS Nanocomposites

Cited by 29 publications

References 49 publications

A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies

A Nanomedicine Structure–Activity Framework for Research, Development, and Regulation of Future Cancer Therapies

A comprehensive analysis and validation of cuproptosis-associated genes across cancers: Overall survival, the tumor microenvironment, stemness scores, and drug sensitivity

Chemoenzymatic Cascade Reaction for Green Cleaning of Polyamide Nanofiltration Membrane

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